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首页> 外文期刊>Life sciences >HYDROXYL RADICAL FORMATION IN DIABETIC RATS INDUCED BY STREPTOZOTOCIN
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HYDROXYL RADICAL FORMATION IN DIABETIC RATS INDUCED BY STREPTOZOTOCIN

机译：链脲佐菌素诱导的糖尿病大鼠体内羟自由基的形成

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Production of hydroxyl radicals was examined in the diabetic rats induced by streptozotocin to prove its involvement to the pathogenesis of diabetes. Hydroxyl radicals generated in plasma, heart muscle, liver and brain of the hyperglycemic rats were quantitatively assayed by trapping hydroxyl radicals with salicylic acid as 2,3- and 2,5-dihydroxybenzoic acid. The concentrations of 2,3- and 2,5-dihydroxybenzoic acid were significantly increased in all the tissues of the diabetic rats. In the brain and heart muscle of the diabetic rats, the increase of 2,3-dihydroxybenzoic acid was more manifest than that of 2,5-dihydroxybenzoic acid, while in liver 2,5-dihydroxybenzoic acid increased markedly. All the values of 2,3-dihydroxybenzoic acid detected in the tissues of the diabetic rats were quite higher than those in control. Hydroxyl radical production and blood glucose concentration were depended almost linearly on the amount of streptozotocin injected to rats up to 60 mg/kg body weight. It was suggested that 2,3-dihydroxybenzoic acid was produced from hydroxyl radicals themselves, while 2,5-dihydroxybenzoic acid was produced by hydroxylation of salicylic acid not only with hydroxyl radicals, but also by enzymatic reaction of microsomal cytochrome-P450. Hydroxyl radical formation may account for some pathological process especially in the heart muscle and brain. [References: 25]
机译：在链脲佐菌素诱导的糖尿病大鼠中检查了羟基自由基的产生，以证明其参与糖尿病的发病机理。通过用水杨酸2,3和2,5-二羟基苯甲酸捕获羟基自由基，定量测定高血糖大鼠血浆，心肌，肝脏和大脑中产生的羟基自由基。在糖尿病大鼠的所有组织中2，3-和2，5-二羟基苯甲酸的浓度均显着增加。在糖尿病大鼠的脑和心肌中，2,3-二羟基苯甲酸的增加比2,5-二羟基苯甲酸的增加更明显，而在肝脏中，2,5-二羟基苯甲酸的增加明显。糖尿病大鼠组织中检测到的所有2,3-二羟基苯甲酸值均明显高于对照组。羟自由基的产生和血糖浓度几乎线性取决于注射给大鼠的链脲佐菌素的量，最高可达60 mg / kg体重。有人认为，2,3-二羟基苯甲酸是由羟基自由基本身产生的，而2,5-二羟基苯甲酸是通过水杨酸不仅与羟基自由基羟基化，而且还通过微粒体细胞色素-P450的酶促反应而生成的。羟自由基的形成可能是某些病理过程的原因，尤其是在心肌和大脑中。 [参考：25]

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