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首页> 外文期刊>Life sciences >Naltrexone potentiates both amnestic and anxiolytic effects of chlordiazepoxide in mice.
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Naltrexone potentiates both amnestic and anxiolytic effects of chlordiazepoxide in mice.

机译：纳曲酮可增强氯二氮卓对小鼠的记忆消除和抗焦虑作用。

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Studies have suggested that opioid antagonists potentiate the anxiolytic effect but not the amnestic action of chlordiazepoxide (CDZ). We investigated the effects of naltrexone (NAL) on the anxiolytic and amnestic effects of CDZ in mice tested in the plus-maze discriminative avoidance task (DAT). Mice are conditioned to choose between two enclosed arms (one of which aversive) while avoiding the two open arms of the apparatus. This task measures memory (time spent in the aversive vs. time in the non-aversive enclosed arms) and anxiety (time spent in the open arms). Mice treated with saline (SAL) or 5 mg/kg NAL, and SAL or 2.5 mg/kg CDZ were submitted to DAT training. The test was performed 24 h later, without aversive stimuli. In the training, NAL + CDZ group showed higher percent time spent in the open arms than all the other groups. In the test, NAL + CDZ (but not SAL + CDZ) group showed higher percent time spent in the aversive enclosed arm than SAL + SAL and NAL + SAL groups. The data suggest that NAL potentiates the small decreases in anxiety and retention induced by a subeffective dose of CDZ.
机译：研究表明，阿片类药物拮抗剂可增强氯二氮卓（CDZ）的抗焦虑作用，但不能增强其记忆消除作用。我们调查了纳曲酮（NAL）对CDZ在迷宫判别规避任务（DAT）中测试的小鼠的抗焦虑和记忆删除作用的影响。小鼠的条件是要在两个封闭的臂（其中一个是厌恶的）之间进行选择，同时避免使用设备的两个开放臂。这项任务测量的是记忆力（厌恶的时间与非平均封闭性手臂的时间）和焦虑（张开双臂的时间）。用盐水（SAL）或5 mg / kg NAL和SAL或2.5 mg / kg CDZ处理的小鼠接受DAT训练。测试在24小时后进行，没有刺激。在训练中，NAL + CDZ组显示出张开双臂花费的时间百分比高于所有其他组。在测试中，与SAL + SAL和NAL + SAL组相比，NAL + CDZ组（而非SAL + CDZ组）在厌恶性闭合臂中花费的时间百分比更高。数据表明，NAL增强了亚有效剂量CDZ引起的焦虑和保留的小幅下降。

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