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首页> 外文期刊>Life sciences >Changes in ceramide levels upon catechins-induced apoptosis in LoVo cells
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Changes in ceramide levels upon catechins-induced apoptosis in LoVo cells

机译：儿茶素诱导LoVo细胞凋亡后神经酰胺水平的变化

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It has been demonstrated that there is difference in the induction of apoptosis in LoVo cells by (-)epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), and (-)-epicatechin (EC). In this study, we explored changes in ceramide levels upon the three catechins-induced apoptosis in LoVo cells. Addition Of C-2- and C-6-ceramide to LoVo cells mimicked EGCG or EGC in leading to apoptotic death. Further measurement of intracellular ceramide content showed that the treatment of LoVo cells with EGCG or EGC resulted in a rapidly transient increase in ceramide content, and then back gradually to base line level, whereas the action of EC was just opposite to that of EGCG or EGC. These results suggest there is difference in the generation of intracellular ceramide by the three catechins and ceramide may take part in the regulation of EGCG- or EGC-induced apoptosis in LoVo cells. (C) 2002 Elsevier Science Inc. All rights reserved. [References: 20]
机译：已经证明，（-）-表没食子儿茶素-3-没食子酸酯（EGCG），（-）-表没食子儿茶素（EGC）和（-）-表儿茶素（EC）在LoVo细胞的凋亡诱导上存在差异。在这项研究中，我们探讨了三类儿茶素诱导LoVo细胞凋亡后神经酰胺水平的变化。在LoVo细胞中添加C-2-和C-6-神经酰胺可模仿EGCG或EGC，从而导致凋亡性死亡。对细胞内神经酰胺含量的进一步测量表明，用EGCG或EGC处理LoVo细胞会导致神经酰胺含量迅速瞬时增加，然后逐渐回到基线水平，而EC的作用与EGCG或EGC的作用恰好相反。这些结果表明，三种儿茶素在细胞内神经酰胺的产生上存在差异，并且神经酰胺可能参与了LoVo细胞中EGCG或EGC诱导的细胞凋亡的调节。 （C）2002 Elsevier Science Inc.保留所有权利。 [参考：20]

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