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首页> 外文期刊>Cell and Tissue Research >Granulocyte-colony stimulating factor: A new player for the enteric nervous system
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Granulocyte-colony stimulating factor: A new player for the enteric nervous system

机译：粒细胞集落刺激因子：肠神经系统的新参与者

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摘要

The enteric nervous system (ENS) controls and modulates gut motility and responds to food intake and to internal and external stimuli such as toxins or inflammation. Its plasticity is maintained throughout life by neural progenitor cells within the enteric stem cell niche. Granulocyte-colony stimulating factor (G-CSF) is known to act not only on cells of the immune system but also on neurons and neural progenitors in the central nervous system (CNS). Here, we demonstrate, for the first time, that G-CSF receptor is present on enteric neurons and progenitors and that G-CSF plays a role in the expansion and differentiation of enteric neural progenitor cells. Cultured mouse ENS-neurospheres show increased expansion with increased G-CSF concentrations, in contrast to CNS-derived spheres. In cultures from differentiated ENS- and CNS-neurospheres, neurite outgrowth density is enhanced depending on the amount of G-CSF in the culture. G-CSF might be an important factor in the regeneration and differentiation of the ENS and might be a useful tool for the investigation and treatment of ENS disorders.
机译：肠神经系统（ENS）控制和调节肠道蠕动，并对食物摄入以及内部和外部刺激（例如毒素或炎症）作出反应。肠干细胞小生境中的神经祖细胞可维持其可塑性。已知粒细胞集落刺激因子（G-CSF）不仅作用于免疫系统的细胞，而且作用于中枢神经系统（CNS）的神经元和神经祖细胞。在这里，我们首次证明，G-CSF受体存在于肠神经元和祖细胞中，并且G-CSF在肠神经祖细胞的扩增和分化中发挥作用。与源自CNS的球体相反，培养的小鼠ENS神经球体显示随着G-CSF浓度的增加而增加的扩张。在来自分化的ENS-和CNS神经球的培养物中，神经突生长密度根据培养物中G-CSF的量而增加。 G-CSF可能是ENS再生和分化的重要因素，并且可能是研究和治疗ENS疾病的有用工具。

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