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首页> 外文期刊>Cell and Tissue Research >Expression of pluripotency factors in echinoderm regeneration
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Expression of pluripotency factors in echinoderm regeneration

机译：多能性因子在棘皮动物再生中的表达

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摘要

Cell dedifferentiation is an integral component of post-traumatic regeneration in echinoderms. As dedifferentiated cells become multipotent, we asked if this spontaneous broadening of developmental potential is associated with the action of the same pluripotency factors (known as Yamanaka factors) that were used to induce pluripotency in specialized mammalian cells. In this study, we investigate the expression of orthologs of the four Yamanaka factors in regeneration of two different organs, the radial nerve cord and the digestive tube, in the sea cucumber Holothuria glaberrima. All four pluripotency factors are expressed in uninjured animals, although their expression domains do not always overlap. In regeneration, the expression levels of the four genes were not regulated in a coordinated way, but instead showed different dynamics for individual genes and also were different between the radial nerve and the gut. SoxB1, the ortholog of the mammalian Sox2, was drastically downregulated in the regenerating intestine, suggesting that this factor is not required for dedifferentiation/regeneration in this organ. On the other hand, during the early post-injury stage, Myc, the sea cucumber ortholog of c-Myc, was significantly upregulated in both the intestine and the radial nerve cord and is therefore hypothesized to play a central role in dedifferentiation/regeneration of various tissue types.
机译：细胞去分化是棘皮动物创伤后再生的重要组成部分。随着去分化细胞变得多能，我们询问这种自发的发展潜力是否与相同的多能性因子（称为Yamanaka因子）的作用有关，这些多能性因子用于诱导特定哺乳动物细胞的多能性。在这项研究中，我们调查了四种山梨因子在直立海参Holothuria glaberrima中两个不同器官（regeneration神经索和消化管）再生中的表达。所有四个多能性因子均在未受伤的动物中表达，尽管它们的表达结构域并不总是重叠。在再生中，这四个基因的表达水平不是以协调的方式调节的，而是对单个基因表现出不同的动力学，并且在nerve神经和肠道之间也不同。哺乳动物Sox2的直系同源基因SoxB1在再生肠中被大幅下调，表明该器官的去分化/再生不需要此因子。另一方面，在损伤后早期，c-Myc的海参直系同源基因Myc在肠和the神经索中均显着上调，因此被认为在其去分化/再生中起重要作用。各种组织类型。

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