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首页> 外文期刊>Life sciences >Antinociceptive effect of topiramate in models of acute pain and diabetic neuropathy in rodents.
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Antinociceptive effect of topiramate in models of acute pain and diabetic neuropathy in rodents.

机译：托吡酯在啮齿类动物的急性疼痛和糖尿病性神经病模型中的抗伤害作用。

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摘要

This study assesses the antinociceptive effect induced by different dosages of topiramate (TP), an anticonvulsant drug that is orally administered in models of neuropathic pain and acute pain in rats and mice, respectively. Orally administered TP (80 mg/Kg) in mice causes antinociception in the first and second phases of a formalin test, while in doses of 20 and 40 mg/Kg it was only effective in the second phase. TP (80 mg/Kg, p.o) also exhibited antinociceptive action in the hot plate test, however, it did not have an effect in the capsaicin test in mice, nor in the model of neuropathic pain in diabetic rats. The antinociceptive effect caused by TP (80 mg/Kg, p.o) in the formalin test was reversed by prior treatment with naloxone (opioid antagonist), but not with glibenclamide (antagonist of the potassium channel), ondansetron (antagonist of the serotonin 5HT3 receptor) or cyproheptadine (antagonist of the serotonin 5HT2A receptor).The data show that TP has an important antinociceptive effect in the models of nociception induced by chemical (formalin) or thermal (hot plate) stimuli, and that the opioid system plays a part in the antinociceptive effect, as shown by formalin.
机译：这项研究评估了不同剂量的托吡酯（TP）（一种在大鼠和小鼠的神经性疼痛和急性疼痛模型中口服给予的抗惊厥药）诱导的镇痛作用。小鼠口服TP（80 mg / Kg）在福尔马林测试的第一阶段和第二阶段引起抗伤害感受，而剂量为20和40 mg / Kg时仅在第二阶段有效。 TP（80 mg / Kg，p.o）在热板试验中也显示出镇痛作用，但是，在小鼠的辣椒素试验中和糖尿病大鼠的神经性疼痛模型中均无作用。福尔马林试验中TP（80 mg / Kg，po）引起的镇痛作用通过纳洛酮（阿片类药物拮抗剂）预先治疗得以逆转，但格列苯脲（钾通道拮抗剂），恩丹西酮（5-羟色胺5HT3受体拮抗剂）则不能逆转。 ）或cyproheptadine（5-羟色胺5HT2A受体的拮抗剂）。数据显示，TP在化学（福尔马林）或热（热板）刺激诱导的伤害感受模型中具有重要的抗伤害感受作用，并且阿片样物质系统在其中起作用如福尔马林所显示的抗伤害作用。

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