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首页> 外文期刊>Life sciences >MATURATION STATUS OF SMALL INTESTINE EPITHELIUM IN RATS DEPRIVED OF DIETARY NUCLEOTIDES
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MATURATION STATUS OF SMALL INTESTINE EPITHELIUM IN RATS DEPRIVED OF DIETARY NUCLEOTIDES

机译：饮食核苷酸剥夺大鼠小肠上皮的成熟状态

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摘要

We describe the changes of several brush-border enzymatic activities in different subpopulations of epithelial cells, separated sequentially from the villus tip-to-crypt axis of the small intestine, induced by deprivation of dietary nucleotides for different periods of time in adult rats. Deprivation of dietary nucleotides lead to a decrease in the content and specific activity of alkaline phosphatase, leucine-aminopeptidase, maltase, sucrase and lactase in the villus tip, but had little effect on the crypt zone. The effect of the nucleotide deprivation on the enzymatic activity progressively increased towards the tip of the villus. Since these enzymes are maturation markers of the intestinal cells, these results support the idea that dietary nucleotides affect the maturation status of small-intestine epithelium. [References: 31]
机译：我们描述了成年大鼠在不同时间段中饮食核苷酸的剥夺引起的上皮细胞不同亚群中几种刷状边界酶活性的变化，这些亚群从小肠的绒毛尖端到隐窝轴依次分离。饮食核苷酸的剥夺导致绒毛尖端碱性磷酸酶，亮氨酸-氨基肽酶，麦芽糖酶，蔗糖酶和乳糖酶的含量和比活性降低，但对隐窝区的影响很小。核苷酸剥夺对酶活性的影响朝着绒毛的尖端逐渐增加。由于这些酶是肠道细胞的成熟标记，因此这些结果支持了饮食核苷酸影响小肠上皮细胞成熟状态的想法。 [参考：31]

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