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首页> 外文期刊>Life sciences >Dietary polyenylphosphatidylcholine decreases cholesterolemia in hypercholesterolemic rabbits: role of the hepato-biliary axis.
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Dietary polyenylphosphatidylcholine decreases cholesterolemia in hypercholesterolemic rabbits: role of the hepato-biliary axis.

机译：饮食中的多烯丙基磷脂酰胆碱可降低高胆固醇血症兔的胆固醇血症：肝胆轴的作用。

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摘要

The aim of this work was to study the cholesterol-lowering mechanisms induced by dietary soybean lecithin in hypercholesterolemic rabbits. Male New Zealand white rabbits (n = 6 in each group) were fed for 10 weeks either a low-fat control C diet, containing 27 g fat/kg, or high-fat diets enriched with 2 g cholesterol/kg and 77 g fat/kg. The high-fat diets contained 50 g lard (L), 50 g soybean triacylglycerol (SO), or 50 g pure soybean phosphatidylcholine (PLE). PLE diet decreased by 30% beta-VLDL-cholesterol, compared with SO diet. HDL2-, HDL3- and LDL-lipid contents were unchanged in the L, SO and PLE groups. In gallbladder bile, amounts of phospholipids, bile salts and cholesterol were significantly increased in PLE group by respectively 45%, 11% and 44%, in comparison with SO group. Intestinal and hepatic Hydroxy Methyl Glutaryl Coenzyme A reductase activities were not increased by PLE diet. Triacylglycerol hepatic content was lower in PLE group than in L or SO groups. Compared with triacylglycerol enriched diet, phosphatidylcholine enriched diet developed significant higher cholesterol- and triacylglycerol-lowering effects by a two-step mechanism: i) by reducing the beta-VLDLs, ii) by enhancing the secretion of bile cholesterol. Such results constitute promising effects of soybean phosphatidylcholine at the hepato-biliary level, in the treatment or prevention of hyperlipidemia and related atherosclerosis.
机译：这项工作的目的是研究饮食大豆卵磷脂诱导的高胆固醇血症兔的降胆固醇机制。雄性新西兰白兔（每组n = 6）被喂食10周，低脂对照C饮食含27 g / kg脂肪，或高脂饮食含2 g胆固醇/ kg和77 g脂肪/公斤。高脂饮食包含50克猪油（L），50克大豆三酰基甘油（SO）或50克纯大豆磷脂酰胆碱（PLE）。与SO饮食相比，PLE饮食减少了30％的β-VLDL-胆固醇。 L，SO和PLE组的HDL2-，HDL3-和LDL-脂质含量没有变化。与SO组相比，PLE组的胆囊胆汁中磷脂，胆汁盐和胆固醇的含量分别显着增加了45％，11％和44％。 PLE饮食不增加肠道和肝脏羟甲基谷氨酰辅酶A的还原酶活性。 PLE组的三酰基甘油肝含量低于L或SO组。与富含三酰甘油的饮食相比，富含磷脂酰胆碱的饮食通过两步机制显着提高了胆固醇和三酰甘油的降低作用：i）通过降低β-VLDLs，ii）通过提高胆汁胆固醇的分泌。这样的结果构成了在肝胆水平上大豆磷脂酰胆碱在治疗或预防高脂血症和相关动脉粥样硬化中的有希望的作用。

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