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首页> 外文期刊>Life sciences >A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats.
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A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats.

机译：高剂量的异戊二烯基长期治疗失去了其对抗氧化酶活性以及对Fischer-344大鼠存活的影响。

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摘要

The survival rate of male Fischer-344/Du rats treated chronically with high doses of deprenyl was investigated. Eighteen month old rats were treated with 1 mg/kg s.c. deprenyl 3 times per week for 13 months. At the age of 31 months, treated rats showed a greater mortality rate with three of 12 rats surviving, while in saline-treated control animals seven of 12 animals survived. No significant differences in superoxide dismutase (SOD) or catalase (CAT) activities in brain regions of control and treated animals were seen at 31 months of age. In contrast, when 27 month old rats were treated in the same manner for one month, significant increases in SOD (both Cu,Zn- and Mn-) and CAT activities were found in substantia nigra, striatum and cerebral cortex, but not in hippocampus. This effect was produced with a wide range of deprenyl doses (0.25-2 mg/kg, but not 4 mg/kg). Although a causal relationship between the two different effects of the drug, i.e. 1) increases in antioxidant enzyme activities and 2) the prolongation of survival of animals, has not been directly demonstrated, the loss of both effects with the high dose of the drug in the present experiment may be taken as circumstantial evidence for their causal relationship.
机译：研究了长期用大剂量异戊二烯基处理的雄性Fischer-344 / Du大鼠的存活率。用1mg / kg s.c.处理18个月大的大鼠。异戊二烯基每周3次，持续13个月。在31个月大时，治疗的大鼠表现出更高的死亡率，其中有12只大鼠中有3只存活，而在盐水治疗的对照动物中，有12只动物中有7只存活。在31个月大时，在对照组和治疗动物的大脑区域中，超氧化物歧化酶（SOD）或过氧化氢酶（CAT）活性均无显着差异。相比之下，当以相同的方式治疗27个月大的大鼠一个月时，黑质，纹状体和大脑皮层中的SOD（Cu，Zn和Mn-）和CAT活性显着增加，而海马体中却没有。在多种异戊二烯基剂量（0.25-2 mg / kg，但不是4 mg / kg）下产生这种效果。尽管尚未直接证明该药物的两种不同作用之间的因果关系，即1）抗氧化酶活性的增加和2）动物存活时间的延长，但在大剂量药物中两种作用的丧失本实验可以作为其因果关系的间接证据。

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