• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Hormonal steroidogenesis in liver and small intestine of the green frog, Rana esculenta L.
【24h】

Hormonal steroidogenesis in liver and small intestine of the green frog, Rana esculenta L.

机译：蛙蛙蛙的肝脏和小肠中激素类固醇生成

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have investigated the potential of autonomous hormonal steroidogenesis in liver and small intestine of male and female frogs, Rana esculenta, during the recovery phase. After incubation of mitochondrial fractions with [4-14C]cholesterol, female liver and intestine formed pregnenolone at a rate of 0.63 and 2.3 pmol/mg protein/h, respectively, whereas conversion by male organs was only c. 0.03 pmol/mg protein/h. Minced tissues preparations transformed [4-14C]pregnenolone into progesterone and 17alpha-hydroxypregnenolone, the former prevailing in the liver, the latter in the intestine. Moreover, both tissues produced 20alpha-dihydropregnenolone, 20alpha-dihydroprogesterone and dehydroepiandrosterone. From incubates with [4-14C]dehydroepiandrosterone, androstenedione and androst-5-ene-3beta, 17beta-diol were identified, the former being more abundant in the liver, the latter in the intestine. These results indicate that both liver and intestine in frog can be independent sources of hormonally active steroids in both sexes.
机译：我们已经研究了恢复期雌雄蛙Rana esculenta在肝脏和小肠中自主激素类固醇生成的潜力。将线粒体级分与[4-14C]胆固醇孵育后，雌性肝脏和肠道分别以0.63和2.3 pmol / mg蛋白质/ h的速率形成孕烯醇酮，而雄性器官的转化率仅为c。 0.03 pmol / mg蛋白质/ h。切碎的组织制剂将[4-14C]孕烯醇酮转化为孕酮和17α-羟基孕烯醇酮，前者在肝脏中盛行，后者在肠道中盛行。此外，两个组织都产生20α-二氢孕烯醇酮，20α-二氢孕酮和脱氢表雄酮。从与[4-14C]脱氢表雄酮，雄烯二酮和雄甾-5-烯-3β的温育中，鉴定出17β-二醇，前者在肝脏中含量更高，后者在肠道中含量更高。这些结果表明，青蛙中的肝脏和肠道都可能是男女中激素活性类固醇的独立来源。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号