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首页> 外文期刊>Life sciences >Platelet-5HT uptake and gastrointestinal symptoms in patients suffering from major depression.
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Platelet-5HT uptake and gastrointestinal symptoms in patients suffering from major depression.

机译：严重抑郁症患者的血小板5HT摄取和胃肠道症状。

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The objective of this study was to determine whether the presence of gastrointestinal symptoms, as defined by item 12 of Hamilton-Rating-Scale for Depression, is related to kinetic characteristics of platelet-5HT uptake in patients with major depression.The clinical picture of depression in patients with severe form of appetite loss with difficulties of eating (item 12 = 2) and weight loss was characterized by the combination of depressed mood with somatic symptoms of anxiety, sleep disturbances, decreased activity and the presence of nausea. The high frequency of relatively low Vmax and Km of 5HT uptake in this group (n = 12), all in the lower range of controls, resulted in significantly lower mean values compared with patients without gastrointestinal symptoms (n = 16; item 12 = 0) or 57 healthy subjects (Vmax = 1.36 +/- 0.27 vs. 2.14 +/- 0.85 vs. 2.05 +/- 0.74 nMol 5HT/10(9)plat.x min; Km = 382 +/- 68 vs. 467 +/- 94 vs. 492 +/- 123 nM respectively).Although our finding needs confirmation, it seems that in the research for serotonergic mechanisms in major depression, it makes sense to look at depressed patients with or without somatic symptoms separately. Based on findings in 5HT transporter knock-out mice (J. Neurosci. 15 (2001) 6348), we assume that the low apparent Vmax of platelet-5HT uptake reflects the low expression of 5HT transporter not only in platelets, but also in the gut mucosa and enteric serotonergic neurons, which probably increases the risk of typical gastrointestinal symptoms such as appetite loss and nausea occurring in some depressed patients.
机译：这项研究的目的是确定严重抑郁症患者的汉密尔顿抑郁量表第12条所定义的胃肠道症状是否与血小板5HT摄取的动力学特征有关。患有严重食欲不振，进食困难（项目12 = 2）和体重减轻的患者，其特征是情绪低落与躯体症状焦虑，睡眠障碍，活动减少和恶心。与对照组相比，该组人群中相对较低的Vmax和Km吸收5HT的高频率（n = 12）均较无胃肠道症状的患者低（n = 16;项目12 = 0） ）或57位健康受试者（Vmax = 1.36 +/- 0.27 vs. 2.14 +/- 0.85 vs. 2.05 +/- 0.74 nMol 5HT / 10（9）plat.x min; Km = 382 +/- 68 vs. 467 + /-94 vs. 492 +/- 123 nM）。尽管我们的发现需要证实，但似乎在重度抑郁症的血清素能机制研究中，分开研究有或没有躯体症状的抑郁症患者是有意义的。基于在5HT转运蛋白敲除小鼠中的发现（J. Neurosci。15（2001）6348），我们认为血小板5HT吸收的低表观Vmax不仅反映了5HT转运蛋白在血小板中的低表达，而且还反映了5HT转运蛋白在血小板中的低表达。肠粘膜和肠5-羟色胺能神经元，可能会增加典型的胃肠道症状的风险，例如在某些抑郁症患者中出现食欲不振和恶心。

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