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首页> 外文期刊>Life sciences >Blockade of striatal 5-HT2 receptors produces retrograde amnesia in rats.
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Blockade of striatal 5-HT2 receptors produces retrograde amnesia in rats.

机译：纹状体5-HT 2受体的阻断在大鼠中产生逆行性健忘症。

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We have recently reported that intrastriatal administration of the serotonin (5-HT) releasing drug p-chloroamphetamine, and of 5-HT itself, produces a significant retention deficit of inhibitory avoidance. It is not known which of the 5-HT receptors are involved in the amnesic effect of serotonin. The present experiment was aimed at determining whether 5-HT2 receptors within the striatum are involved in memory consolidation. Ketanserine (0.5, 1.0, 2.0, or 4.0 ng) was infused bilaterally into the striatum of Wistar rats immediately after training of inhibitory avoidance, and retention of the task was measured 24 h later. A dose-dependent retention deficit was found. Together with the results from appropriate control groups, the results strongly suggest that striatal 5-HT2 receptors participate in memory consolidation of this aversive task.
机译：我们最近报道，纹状体内施用5-羟色胺（5-HT）释放药物对氯苯丙胺和5-HT本身，会产生抑制回避的显着保留缺陷。 5-羟色胺的记忆删除作用与5-HT受体有关。本实验旨在确定纹状体内的5-HT2受体是否参与记忆巩固。抑制性抑制训练结束后，立即向双侧向Wistar大鼠的纹状体中注入Ketanserine（0.5、1.0、2.0或4.0 ng），并在24小时后测量任务的保留。发现剂量依赖性的保留缺陷。与适当对照组的结果一起，结果强烈表明纹状体5-HT 2受体参与了该厌恶任务的记忆巩固。

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