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首页> 外文期刊>Life sciences >Association of single nucleotide polymorphisms of nicotinic acetylcholine receptor subunits with cervical neoplasia.
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Association of single nucleotide polymorphisms of nicotinic acetylcholine receptor subunits with cervical neoplasia.

机译：烟碱样乙酰胆碱受体亚基的单核苷酸多态性与宫颈肿瘤的关系。

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摘要

Cholinergic signaling, particularly in response to non-physiological ligands like nicotine, stimulates carcinogenesis of a variety of tissue types including epithelia of the cervix uteri. Cholinergic signaling is mediated by nicotinic acetylcholine receptors (nAChRs), which are pentamers formed by subsets of 16 nAChR subunits. Recent literature suggests that single nucleotide polymorphisms (SNPs) of some of these subunits, notably alpha5, are risk factors for developing lung cancer in smokers as well as in non-smokers.We have studied the prevalence of four SNPs in the alpha5, alpha9, and beta1 subunits, which are expressed in cervical cells, in 456 patients with cervical cancers, precursor lesions, and healthy controls from two cohorts in Mexico.A SNP in the alpha9 subunit, the G allele of rs10009228 (alpha9, A>G) shows a significant trend in the combined cohort, indicating that this allele constitutes a risk factor for neoplastic progression. The A allele of the SNP rs16969968 (alpha5, G>A), which correlates with the development of lung cancer, shows a non-significant trend to be associated with cervical lesions. Two other SNPs, rs55633891 (alpha9, C>T) and rs17856697 (beta1, A>G), did not exhibit a significant trend.Our study points to a potential risk factor of cervical carcinogenesis with importance for DNA diagnosis and as a target for intervention.
机译：胆碱能信号传导，特别是对诸如尼古丁之类的非生理性配体的反应，会刺激包括宫颈上皮在内的多种组织类型的癌变。胆碱能信号传导由烟碱乙酰胆碱受体（nAChRs）介导，烟碱乙酰胆碱受体是由16个nAChR亚基的子集形成的五聚体。最近的文献表明，其中一些亚基的单核苷酸多态性（SNP），尤其是alpha5，是吸烟者和非吸烟者罹患肺癌的危险因素。我们研究了alpha5，alpha9，墨西哥两个队列的456名患有宫颈癌，前体病变和健康对照的患者中，其在宫颈细胞中的表达水平和β1亚基。α9亚基中的SNP，即rs10009228的G等位基因（α9，A> G）显示合并队列的显着趋势，表明该等位基因构成了肿瘤进展的危险因素。 SNP rs16969968的A等位基因（alpha5，G> A）与肺癌的发展相关，显示出与宫颈病变相关的非显着趋势。 rs55633891（alpha9，C> T）和rs17856697（beta1，A> G）这两个SNP没有显着趋势。我们的研究指出了宫颈癌的潜在危险因素，对DNA诊断很重要，并且是宫颈癌的靶标。介入。

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