• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >The short and long term effects of docetaxel chemotherapy on rodent object recognition and spatial reference memory
【24h】

The short and long term effects of docetaxel chemotherapy on rodent object recognition and spatial reference memory

机译：多西他赛化疗对啮齿动物识别和空间参考记忆的短期和长期影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aims Previous animal studies have examined the potential for cytostatic drugs to induce learning and memory deficits in laboratory animals but, to date, there is no pre-clinical evidence that taxanes have the potential to cause cognitive impairment. Therefore our aim was to explore the short- and long-term cognitive effects of different dosing schedules of the taxane docetaxel (DTX) on laboratory rodents. Main methods Healthy male hooded Wistar rats were treated with DTX (6 mg/kg, 10 mg/kg) or physiological saline (control), once a week for 3 weeks (Experiment 1) or once only (10 mg/kg; Experiment 2). Cognitive function was assessed using the novel object recognition (NOR) task and spatial water maze (WM) task 1 to 3 weeks after treatment and again 4 months after treatment. Key findings Shortly after DTX treatment, rats perform poorly on NOR regardless of treatment regimen. Treatment with a single injection of 10 mg/kg DTX does not appear to induce sustained deficits in object recognition or peripheral neuropathy. Significance Overall these findings show that treatment with the taxane DTX in the absence of cancer and other anti-cancer treatments causes cognitive impairment in healthy rodents.
机译：目的先前的动物研究已经研究了抑制细胞生长的药物在实验动物中诱发学习和记忆缺陷的潜力，但迄今为止，尚无临床前证据表明紫杉烷具有引起认知障碍的潜力。因此，我们的目的是探讨紫杉烷多西紫杉醇（DTX）不同给药方案对实验室啮齿动物的短期和长期认知作用。主要方法用DTX（6 mg / kg，10 mg / kg）或生理盐水（对照）治疗健康的雄性带帽Wistar大鼠，每周一次，连续3周（实验1）或仅一次（10 mg / kg;实验2）。 ）。在治疗后1至3周以及治疗后4个月，使用新型物体识别（NOR）任务和空间水迷宫（WM）任务评估认知功能。主要发现DTX治疗后不久，无论采用何种治疗方案，大鼠的NOR表现均较差。单次注射10 mg / kg DTX的治疗似乎并未引起物体识别或周围神经病变的持续缺陷。重要性总的来说，这些发现表明，在没有癌症的情况下使用紫杉烷DTX进行治疗和其他抗癌治疗会导致健康啮齿动物的认知障碍。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号