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首页> 外文期刊>Life sciences >A TUMOR CELL GROWTH INHIBITOR FROM POLYGONUM HYPOLEUCUM OHWI
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A TUMOR CELL GROWTH INHIBITOR FROM POLYGONUM HYPOLEUCUM OHWI

机译：太子参中的肿瘤细胞生长抑制剂

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Polygonum hypoleucum Ohwi (P. hypoleucum Ohwi) has been used as a Chinese medicine for a long time. In the present study, four anthraquinones, emodin, emodin 1-O-beta-D-glucoside (49A), physcion (62A), and physcion 1-O-beta-D-glucoside (50A) were identified from P. hypoleucum Ohwi and their inhibitory effects on various tumor cells proliferation were investigated. On a percentage basis, emodin had the highest suppressing activity on the various tumor cells proliferation. At 10 mu g/ml, the percentage inhibition on K562 cells proliferation for emodin, 49A, 62A, and 50A were 97+/-3.4%, 18+/-7.3%, 24+/-3.6%, and 31+/-8.9%, respectively. However, inhibitory activities of 10 mu g/ml of emodin, 49A, 62A, or 50A on Raji cells proliferation were 96+/-5.0%, 25+/-5.0%, 22+/-3.2%, and 28+/-4.3%, respectively. It was also found that the both C1 and C3 positions of emodin were important for antitumor action. The IC50s of emodin, 49A, 62A, and 50A on various tumor cells were also calculated. The IC50 of emodin on K562 cells was significantly lower than on Raji, HeLa, Calu-1, Wish, and Vero cells (1.5+/-0.2 vs. 2.8+/-0.4 mu g/ml, P < 0.01; 1.5+/-0.2 vs. 8.4+/-1.6 mu g/ml; 1.5+/-0.2 vs. 8.9+/-1.0 mu g/ml; 1.5+/-0.2 vs. 8.7+/-0.5 mu g/ml; 1.5+/-0.2 vs. 3.5+/-0.12 mu g/ml; P < 0.001). The results indicated that K562 and Raji cells were more sensitive to emodin treatment. Cell viability test indicated that inhibitory effect of emodin on various tumor cell lines was not through direct cytotoxicity. It suggested P. hypoleucum Ohwi included a tumor cell growth inhibitor. [References: 24]
机译：何首乌（P. hypoleucum Ohwi）作为中药已使用了很长时间。在本研究中，从次生疟原虫Ohwi中鉴定了四种蒽醌，大黄素，大黄素1-O-β-D-葡萄糖苷（49A），physcion（62A）和physcion1-O-β-D-葡萄糖苷（50A）。研究了它们对多种肿瘤细胞增殖的抑制作用。大黄素对各种肿瘤细胞的增殖具有最高的抑制活性。大黄素，49A，62A和50A在10μg / ml时对K562细胞增殖的抑制百分比分别为97 +/- 3.4％，18 +/- 7.3％，24 +/- 3.6％和31 +/-分别为8.9％。但是，大黄素10μg/ ml，49A，62A或50A对Raji细胞增殖的抑制活性为96 +/- 5.0％，25 +/- 5.0％，22 +/- 3.2％和28 +/-。分别为4.3％。还发现大黄素的C1和C3位置对于抗肿瘤作用都很重要。还计算了大黄素，49A，62A和50A在各种肿瘤细胞上的IC50。大黄素在K562细胞上的IC50显着低于Raji，HeLa，Calu-1，Wish和Vero细胞（1.5 +/- 0.2对2.8 +/- 0.4μg / ml，P <0.01; 1.5 + / -0.2对8.4 +/- 1.6μg / ml; 1.5 +/- 0.2对8.9 +/- 1.0μg / ml; 1.5 +/- 0.2对8.7 +/- 0.5μg / ml; 1.5+ /-0.2 vs.3.5 +/- 0.12μg / ml; P <0.001）。结果表明，K562和Raji细胞对大黄素处理更为敏感。细胞活力测试表明大黄素对多种肿瘤细胞系的抑制作用不是通过直接的细胞毒性。这表明P. hypoleucum Ohwi包含一种肿瘤细胞生长抑制剂。 [参考：24]

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