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EFFECT OF VALPROATE ON THE METABOLISM OF THE CENTRAL NERVOUS SYSTEM [Review]

机译：丙戊酸酯对中枢神经系统代谢的影响[综述]

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The effects of valproate on brain energy and lipid metabolism is reviewed. Increasing evidence suggests that valproate uses the monocarboxylic acid carrier in order to cross the blood brain barrier (BBB) and the neural cell plasma membranes. The uptake of valproate into the brain through this mechanism would compete with the uptake of energy precursors, such as the monocarboxylic acids 3-hydroxybutyrate, lactate or pyruvate and with some amino acids, but not with glucose. This could impair brain fuel utilization, specially during the neonatal period or childhood, when lactate or 3-hydroxybutyrate furnishes alternative substrates to glucose for the brain. It is concluded that valproate interference with energy metabolism may have implications for the therapeutic action of the drug, stressing the possibility that valproate-mediated alterations in brain lipid synthesis may contribute to the pharmacological action of the drug. [References: 126]
机译：丙戊酸对脑能量和脂质代谢的影响进行了审查。越来越多的证据表明，丙戊酸酯使用一元羧酸载体来穿越血脑屏障（BBB）和神经细胞质膜。通过这种机制将丙戊酸盐摄入大脑会与能量前体的摄取竞争，例如3-羟基丁酸一元羧酸，乳酸或丙酮酸以及一些氨基酸，但不能与葡萄糖竞争。这可能会损害大脑的燃料利用，特别是在新生儿期或儿童期，当乳酸或3-羟基丁酸酯为大脑提供葡萄糖的替代底物时。结论是丙戊酸盐对能量代谢的干扰可能对药物的治疗作用有影响，强调了丙戊酸盐介导的脑脂质合成改变可能有助于药物的药理作用的可能性。 [参考：126]

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