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首页> 外文期刊>Life sciences >IN VIVO INTERACTION OF BACLOFEN, TRH AND SEROTONIN ON PRL AND TSH SECRETION IN THE DEVELOPING AND ADULT MALE AND FEMALE RATS
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IN VIVO INTERACTION OF BACLOFEN, TRH AND SEROTONIN ON PRL AND TSH SECRETION IN THE DEVELOPING AND ADULT MALE AND FEMALE RATS

机译：发育中和成年成年大鼠和雌性大鼠体内青霉素，TRH和血清素对PRL和TSH分泌的体内相互作用

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Gamma-aminobutyric acid (GABA) is involved in the neural control of hypophyseal hormones, including PRL and TSH. In the present work we investigated the ontogeny of the effect of baclofen, a GABA B agonist, on basal PRL and TSH release and in the presence of releasing stimulus which act at two different levels: TRH, at the hypophyseal level, and serotonin, at the central nervous system. Ages studied were 4, 12, 20, 28-29, 37-38 day-old and adult male and female animals. Rats of each age and sex were separated in groups and each group received two intraperitoneally injections, one 45 minutes after the other: saline-saline, saline-TRH, baclofen-saline, baclofen-TRH, saline-serotonin or baclofen-serotonin. Rats were decapitated 15 minutes after the last injection and serum hormones were measured by RIA. Baclofen (7 mg/kg) significantly elevated basal prolactin levels at 4, 12 and 20 days of age and the stimulating effect increased with age. At 28 days of age baclofen significantly inhibited PRL whereas from 38 days of age onwards it had no effect on basal PRL levels. No sex differences were evident. Interaction of TRH (4 mu g/kg) and baclofen on PRL secretion resulted in an additive effect on days 4 and 12, this effect was not observed when baclofen was administered with serotonin (10 mg/kg). In 28 day-old and older animals baclofen completely blunted the PRL releasing effect of TRH or serotonin. Again, no sex differences were observed. With regard to TSH, baclofen did not alter either basal or TRH stimulated TSH secretion regardless of sex and age. The present experiments indicate that GABA B receptors are involved in the regulation of basal and stimulated PRL secretion from the first days of life to adulthood. Receptor activation results in stimulation or inhibition of PRL release depending on the age of the animals and the site of action. This GABA B regulation of PRL secretion is sex independent. In contrast, pituitary GABA B receptors do not seem to be involved in the regulation of TSH secretion. [References: 36]
机译：γ-氨基丁酸（GABA）参与神经下垂激素的控制，包括PRL和TSH。在当前的工作中，我们研究了GABA B激动剂巴氯芬对基础PRL和TSH释放以及在存在两种不同水平的释放刺激的情况下的作用的个体发育：下垂体水平的TRH和5-羟色胺的水平。中枢神经系统。研究的年龄为4、12、20、28-29、37-38日龄和成年雄性和雌性动物。将不同年龄和性别的大鼠分成几组，每组一次腹膜内注射两次，每次45分钟后：生理盐水，生理盐水-TRH，巴氯芬-盐水，巴氯芬-TRH，盐水5-羟色胺或巴氯芬-5-羟色胺。最后一次注射后15分钟，将大鼠断头并通过RIA测量血清激素。 Baclofen（7 mg / kg）在4、12和20天龄时基础催乳素水平显着升高，并且刺激作用随年龄的增长而增加。在第28天时，巴氯酚显着抑制PRL，而从第38天起，它对基础PRL水平无影响。没有明显的性别差异。 TRH（4μg / kg）和巴氯芬对PRL分泌的相互作用在第4天和第12天产生累加效应，当巴氯芬与5-羟色胺（10 mg / kg）一起给药时未观察到这种效应。在28日龄和更年长的动物中，巴氯芬完全减弱了TRH或5-羟色胺的PRL释放作用。同样，没有观察到性别差异。关于TSH，无论性别和年龄，巴氯芬均不会改变基础或TRH刺激的TSH分泌。本实验表明，从出生的第一天到成年，GABA B受体参与了基础和受激PRL分泌的调节。取决于动物的年龄和作用部位，受体活化导致PRL释放的刺激或抑制。 PRA分泌的这种GABA B调节与性别无关。相反，垂体GABA B受体似乎不参与TSH分泌的调节。 [参考：36]

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