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首页> 外文期刊>Life sciences >Plant derived estrogens relax rat mesenteric artery in vitro.
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Plant derived estrogens relax rat mesenteric artery in vitro.

机译：植物来源的雌激素可在体外放松大鼠肠系膜动脉。

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摘要

The aim of this study was to investigate whether plant derived estrogens have the same relaxing effects in vitro as estradiol-17beta on arterial smooth muscle. The mesenteric arterial rings of female and male Wistar rats were studied. The relaxing effects of estradiol-17beta, genistein, daidzein and beta-sitosterol were determined, with particular focus on the role of endothelium. B-sitosterol had no relaxing effect on the arteries. Estradiol-17beta, genistein and daidzein relaxed noradrenaline, potassium chloride and calcium chloride precontracted arterial rings endothelium-independently. The relaxation responses were also independent of gender. Neither the removal of endothelium, nor the inhibition prostacyclin or nitric oxide synthesis, had any effect on the relaxation responses. The exact mechanism of these findings is still unclear.
机译：这项研究的目的是调查植物源性雌激素在体外是否具有与雌二醇17β相同的舒张作用，对动脉平滑肌有促进作用。研究雌性和雄性Wistar大鼠的肠系膜动脉环。确定了雌二醇-17β，金雀异黄素，大豆苷元和β-谷固醇的松弛作用，尤其着眼于内皮的作用。 B-谷固醇对动脉没有松弛作用。雌二醇17β，金雀异黄素和黄豆苷元可独立于内皮释放去甲肾上腺素，氯化钾和氯化钙预收缩的动脉环。放松反应也与性别无关。内皮的去除，前列环素的抑制或一氧化氮的合成都对松弛反应没有任何影响。这些发现的确切机制仍不清楚。

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