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Effect of spermine on lipid profile and HDL functionality in the streptozotocin-induced diabetic rat model

机译：精胺对链脲佐菌素诱导的糖尿病大鼠模型中脂质谱和HDL功能的影响

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This study aimed to investigate the effect of spermine (Spm) as a chemical chaperone and glycation inhibitor on the lipid profile and HDL functionality in the short- and long-term treatment of the STZ-induced diabetic rats. Male Wistar rats were divided into 4 groups (control, n=7; diabetic, n = 9). Two groups (named 2 and 3) were injected intraperitoneally with streptozotocin. Control rats (named 1 and 4) were injected with vehicle alone. The treatment of diabetic and control animals (groups 3 and 4) with 60 mu mol/l of Spm in drinking water was begun. The study continued up to the end of the fifth month. The serum glucose and insulin level, AGE formation, lipid profile, paraoxonase 1 (PON1), and lecithin: cholesterol acyl transferase (LCAT) activities were measured. Significantly lower plasma PON1, and LCAT activities and higher serum AGE, TG, TC and LDL-c, and lower HDL-c were seen in diabetic rats as compared to control groups (P<0.01). The increased AGE, TG, TC and LDL-c levels in diabetic groups decreased gradually after receiving Spm. In addition, due to Spm administration, an increase in the HDL-c level was observed after the first month of the experiment (P<0.01). The increase in the PON1 and LCAT activities in the diabetic group that received Spm was significant after the second and the forth month of the experiment, P<0.02 and P<0.05, respectively. In conclusion, spermine administration attenuated the changed parameters to near normal values in diabetic rats. Spermine, despite a lack of significant changes on glucose metabolism and insulin secretion, was found to improve diabetes complications. (C) 2007 Elsevier Inc. All rights reserved.
机译：这项研究旨在调查在短期和长期治疗STZ诱导的糖尿病大鼠中，作为化学伴侣和糖基化抑制剂的精胺（Spm）对脂质分布和HDL功能的影响。将雄性Wistar大鼠分成4组（对照组，n ＝ 7;糖尿病，n ＝ 9）。两组腹膜内注射链脲佐菌素（分别为2和3）。对照大鼠（分别命名为1和4）被注射媒介物。开始在饮用水中用60μmol/ l的Spm处理糖尿病和对照动物（第3组和第4组）。研究一直持续到第五个月末。测量了血清葡萄糖和胰岛素水平，AGE形成，脂质分布，对氧磷酶1（PON1）和卵磷脂：胆固醇酰基转移酶（LCAT）活性。与对照组相比，糖尿病大鼠血浆PON1和LCAT活性明显降低，血清AGE，TG，TC和LDL-c升高，HDL-c降低（P <0.01）。接受Spm后，糖尿病组的AGE，TG，TC和LDL-c水平升高。另外，由于施用Spm，在实验的第一个月后观察到HDL-c水平升高（P <0.01）。在实验的第二个月和第四个月之后，接受Spm的糖尿病组的PON1和LCAT活性增加显着，分别为P <0.02和P <0.05。总之，在糖尿病大鼠中，精胺给药可将改变的参数减至接近正常值。尽管精氨酸在葡萄糖代谢和胰岛素分泌方面没有显着变化，但发现它可以改善糖尿病并发症。 （C）2007 Elsevier Inc.保留所有权利。

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