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首页> 外文期刊>Life sciences >Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats.
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Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats.

机译：大鼠坐骨神经慢性压迫性损伤所致后爪负重差异的药理特性。

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AIMS: We examined the possible involvement of spontaneous on-going pain in the rat chronic constriction injury (CCI) model of neuropathic pain. MAIN METHODS: The development of weight bearing deficit, as an index of spontaneous on-going pain, was investigated in comparison to that of mechanical allodynia in CCI rats. We also examined the effects of morphine and a gabapentin analogue (1S, 3R)-3-methyl-gabapentin (3-M-gabapentin) on both the CCI-induced weight bearing deficit and mechanical allodynia. KEY FINDINGS: Rats with CCI demonstrated a significant reduction in weight bearing of the injured limb with a peak at a week post-operation, which was followed by a gradual recovery for over 7 weeks. The time course of development and recovery of CCI-induced weight bearing deficit appeared to follow that of foot deformation of the affected hind limb. CCI also evoked mechanical allodynia that was fully developed on a week post-operation, but showed no recovery for at least 8 weeks. 3-M-gabapentin significantly inhibited CCI-induced mechanical allodynia, but not weight bearing deficit, at 100 mg/kg p.o. Likewise, morphine was without significant effect on CCI-induced weight bearing deficit at the dose (3 mg/kg, s.c.) that could almost completely inhibit mechanical allodynia, whereas it inhibited both mechanical allodynia and weight bearing deficit at 6 mg/kg, s.c. SIGNIFICANCE: The present findings suggest that CCI-induced weight bearing deficit is not a consequence of mechanical allodynia, but is attributable to spontaneous on-going pain. The rat CCI model of neuropathic pain thus represents both spontaneous on-going pain and mechanical allodynia.
机译：目的：我们研究了自发性持续性疼痛可能与神经性疼痛的大鼠慢性收缩损伤（CCI）模型有关。主要方法：与机械性异常性疼痛相比，研究了自发性持续疼痛指标承重不足的发展，并与之进行了对比。我们还研究了吗啡和加巴喷丁类似物（1S，3R）-3-甲基-加巴喷丁（3-M-加巴喷丁）对CCI引起的负重和机械性异常性疼痛的影响。主要发现：CCI大鼠表现出受伤肢体的负重显着降低，在术后一周出现峰值，随后逐渐恢复超过7周。 CCI引起的负重缺乏症的发展和恢复的时间进程似乎遵循受影响的后肢的脚变形的时间进程。 CCI还引起了机械异常性疼痛，该异常性疼痛在术后一周内已完全发展，但至少在8周内没有恢复。 3-M-加巴喷丁在100 mg / kg p.o时可显着抑制CCI引起的机械性异常性疼痛，但不能抑制体重不足。同样，吗啡在几乎可以完全抑制机械性异常性疼痛的剂量（3 mg / kg，s.c.）下对CCI引起的体重减轻也没有显着影响，而在6 mg / kg s.c.时，吗啡同时抑制机械性异常性疼痛和体重减轻。意义：本研究结果表明，CCI引起的负重不足不是机械性异常性疼痛的结果，而是归因于持续的自发性持续疼痛。因此，神经性疼痛的大鼠CCI模型既代表自发进行性疼痛，也代表机械性异常性疼痛。

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