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首页> 外文期刊>Life sciences >PASSAGE OF PEPTIDES ACROSS THE BLOOD-BRAIN BARRIER - PATHOPHYSIOLOGICAL PERSPECTIVES [Review]
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PASSAGE OF PEPTIDES ACROSS THE BLOOD-BRAIN BARRIER - PATHOPHYSIOLOGICAL PERSPECTIVES [Review]

机译：穿越血脑屏障的肽的传播-生理生理学观点[综述]

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摘要

Blood-borne peptides are capable of affecting the central nervous system (CNS) despite being separated from the CNS by the blood-brain barrier (BBB), a monolayer comprised of brain endothelial and ependymal cells. Blood-borne peptides can directly affect the CNS after they cross the BBB by nonsaturable and saturable transport mechanisms. The ability of peptides to cross the BBB to a meaningful degree suggests that the BBB may act as a modulatory pathway in the exchange of informational molecules between the brain and tile peripheral circulation. The permeability of the BBB to peptides is a regulatory process affect by developmental, physiological, and pathological events. This regulation sets the stage for the relation between peptides and the BBB to be involved in pathophysiological events. For example, some of the classic actions of melanocortins on the CNS are explained by their abilities to cross the BBB, whereas aspects of feeding and alcohol-related behaviors are associated with the passage of other specific peptides across the BBB. The BBB should no longer be considered a static barrier but should be recognized as a regulatory interface controlling the exchange of informational molecules, such as peptides, between the blood and CNS. [References: 182]
机译：尽管血传肽被血脑屏障（BBB）与中枢神经系统分开，但它仍能影响中枢神经系统（CNS），血脑屏障是由脑内皮细胞和室管膜细胞组成的单层。血源肽在通过血脑屏障后，会通过不饱和和饱和的转运机制直接影响中枢神经系统。肽穿过BBB的能力达到了一个有意义的程度，表明BBB可能在大脑和瓦楞末梢循环之间的信息分子交换中充当调节途径。 BBB对肽的通透性是受发育，生理和病理事件影响的调节过程。该规定为参与病理生理事件的肽与血脑屏障之间的关系奠定了基础。例如，黑皮质素对中枢神经系统的某些经典作用是通过它们穿越血脑屏障的能力来解释的，而进食和酒精相关行为的方面则与其他特定肽通过血脑屏障的通过有关。 BBB不应再被视为静态屏障，而应被视为控制血液和CNS之间信息分子（例如肽）交换的调节界面。 [参考：182]

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