...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Muscle sarcomas and alopecia in A/J mice chronically treated with nicotine.
【24h】

Muscle sarcomas and alopecia in A/J mice chronically treated with nicotine.

机译：长期接受尼古丁治疗的A / J小鼠的肌肉肉瘤和脱发。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To evaluate the pathobiologic effects of long-term treatment with nicotine of A/J mice susceptible to tobacco-induced lung carcinogenesis.Experimental group of mice received subcutaneous injections of the LD(50) dose of (-)nicotine hydrogen tartrate of 3 mg/kg/day, 5 days per week for 24 months, and control group received the vehicle phosphate-buffered saline.Nicotine treated mice, 78.6%, but none of control of mice, developed neoplasms originating from the uterus or skeletal muscle. Examination of the uterine neoplasms revealed leiomyosarcomas, composed of whorled bundles of smooth-muscle like cells with large and hyperchromatic nuclei. Sections of the thigh neoplasms revealed densely cellular tumors composed of plump spindle cells, with occasional formation of 'strap' cells, containing distorted striations. Both neoplasms were positive for desmin staining. A solitary pulmonary adenoma with papillary architecture also occurred in one nicotine treated mouse. Experimental mice also developed transient balding starting as small patches of alopecia that progressed to distinct circumscribed areas of complete hair loss or large areas of diffuse hair loss.We demonstrate for the first time that chronic nicotine treatment can induce the development of muscle sarcomas as well as transient hair loss. These findings may help explain the association of childhood rhabdomyosarcoma with parental smoking and earlier onset of balding in smokers. It remains to be determined whether the pathobiologic effects of nicotine result from its receptor-mediated action and/or its tissue metabolites cotinine and N'-nitrosonornicotine, or toxic effects of reactive oxygen species activated due to possible intracellular accumulation of nicotine.
机译：为了评估长期使用尼古丁对易受烟草诱导的肺致癌作用的A / J小鼠的病理生物学作用，实验组的小鼠皮下注射了LD（50）剂量的酒石酸（-）烟碱氢盐3 mg /公斤/天，每周5天，连续24个月，对照组接受媒介物磷酸盐缓冲盐水。尼古丁治疗的小鼠中，有78.6％的小鼠发育为子宫或骨骼肌肿瘤，但无对照组。子宫肿瘤检查显示平滑肌肉瘤，由平滑肌样细胞的螺旋状成束的束状组成，具有大而增高的核。大腿肿瘤的切片显示出密集的细胞瘤，由丰满的纺锤体细胞组成，偶有“带状”细胞形成，包含扭曲的条纹。两种肿瘤均对结蛋白染色呈阳性。一只尼古丁治疗的小鼠中还出现了具有乳头状结构的孤立性肺腺瘤。实验性小鼠还出现了短暂的秃顶，从小斑秃开始，逐渐发展到明显的完全脱发的边界区域或大范围的散发性脱发。我们首次证明了慢性尼古丁治疗可以诱导肌肉肉瘤的发展以及短暂脱发。这些发现可能有助于解释儿童横纹肌肉瘤与父母吸烟以及吸烟者秃发较早的关联。尼古丁的病理生物学作用是由于其受体介导的作用和/或其组织代谢产物可替宁和N'-硝基异烟碱，还是由于可能的尼古丁的细胞内积累而活化的活性氧的毒性作用，尚待确定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号