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首页> 外文期刊>Life sciences >Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling
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Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling

机译：Wnt /β-catenin信号转导介导的乌头块茎提取物对毛发生长的促进作用

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Aims: The activation of Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis by stimulating bulge stem cells. This study was to obtain the activator of Wnt/β-catenin signaling pathway from natural products and to determine whether this activator can induce anagen hair growth in mice. Main methods: To identify materials that activate Wnt/β-catenin signaling pathway, 800 natural product extracts were screened using pTOPFlash assay and neural progenitor cell (NPC) differentiation assay. A selected extract was further tested for its effects on alkaline phosphatase (ALP) activity in human immortalized dermal papilla cell (iDPC) and the proliferation in iDPC and immortalized rat vibrissa DPC (RvDP). Finally, hair growth-promoting effects were evaluated in the dorsal skin of C57BL/6 mice. Key findings: Aconiti Ciliare Tuber (ACT) extract was one of the most active materials in both pTOPFlash and NPC differentiation assays. It promoted the differentiation of NPC cells even under proliferation-stimulating conditions (basic fibroblast growth factor: bFGF). It also increased ALP activity and proliferation of iDPC in dose-dependent manners, and it stimulated the induction of the anagen hair growth in C57BL/6 mice. These results suggest that ACT extract activates the Wnt/β-catenin signaling pathway by enhancing β-catenin transcription and has the potential to promote the induction of hair growth via activation of the stem cell activity of the dermal papilla cells. Significance: This is the first report indicating benefits of ACT extract in hair loss prevention by triggering the activation of Wnt/β-catenin signaling pathway and induction of the anagen hair growth in mice.
机译：目的：Wnt /β-catenin信号通路的激活在刺激毛囊干细胞中在毛囊形态发生中起重要作用。这项研究是从天然产物中获得Wnt /β-catenin信号通路的激活剂，并确定该激活剂是否可以诱导小鼠毛发生长毛发生长。主要方法：为了鉴定激活Wnt /β-catenin信号通路的物质，使用pTOPFlash分析和神经祖细胞（NPC）分化分析筛选了800种天然产物提取物。进一步测试了所选提取物对人永生化真皮乳头细胞（iDPC）中碱性磷酸酶（ALP）活性以及iDPC和永生化大鼠触须DPC（RvDP）中增殖的影响。最后，在C57BL / 6小鼠的背部皮肤中评估了促进毛发生长的作用。主要发现：附子纤毛提取物（ACT）提取物是pTOPFlash和NPC分化测定中活性最高的物质之一。即使在增殖刺激条件下（碱性成纤维细胞生长因子：bFGF），它也能促进NPC细胞的分化。它还以剂量依赖性方式增加了ALP活性和iDPC的增殖，并刺激了C57BL / 6小鼠的毛发生长毛诱导。这些结果表明ACT提取物通过增强β-catenin转录来激活Wnt /β-catenin信号传导途径，并且具有通过激活真皮乳头细胞的干细胞活性来促进毛发生长的诱导的潜力。启示：这是第一份表明ACT提取物通过触发Wnt /β-catenin信号传导途径的激活和诱导毛发生长毛发生的预防脱发的益处的报道。

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