Cyclo(His-Pro) augments the insulin response to oral glucose in rats.

Mizumo H; Svec F; Prasad C; Hilton C

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Cyclo(His-Pro) augments the insulin response to oral glucose in rats.

机译：Cyclo（His-Pro）增强大鼠对口服葡萄糖的胰岛素反应。

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Cyclo(His-Pro) (CHP) is a gut-brain peptide found in rat and man. Since plasma levels of CHP are altered by oral glucose ingestion, we wondered whether exogenous CHP might alter the insulin response to oral glucose ingestion. To this end, rats were given 3g/kg oral glucose load with either saline or increasing doses of CHP and plasma levels of insulin, C-peptide and glucose were measured. We found mean insulin but not C-peptide excursions and area under the insulin but not C-peptide response curves (AUC) were significantly higher in the CHP groups than controls despite similar glucose responses. In summary, these data show that in rats receiving oral glucose, CHP causes higher insulin excursions without any change in C-peptide suggesting that CHP may decrease hepatic insulin clearance.

机译：Cyclo（His-Pro）（CHP）是在大鼠和人类中发现的肠脑肽。由于血浆CHP会因口服葡萄糖摄入而改变，因此我们想知道外源CHP是否会改变胰岛素对口服葡萄糖摄入的反应。为此，给大鼠口服3g / kg的口服葡萄糖负荷，加生理盐水或增加剂量的CHP，并测量血浆胰岛素，C肽和葡萄糖水平。我们发现，尽管有相似的葡萄糖反应，CHP组中的平均胰岛素而非C肽漂移和胰岛素下方面积而不是C肽反应曲线（AUC）明显高于对照组。总之，这些数据表明，在接受口服葡萄糖的大鼠中，CHP引起较高的胰岛素偏移，而C肽没有任何变化，这表明CHP可能会降低肝脏胰岛素清除率。

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《Life sciences》 |1997年第6期|共6页
作者
Mizumo H; Svec F; Prasad C; Hilton C;
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正文语种 eng
中图分类基础医学;
关键词
Glucose; Insulin; Liver; Peptides; Cyclic; Piperazines; Blood Glucose; C-Peptide; 葡萄糖; 胰岛素; 肝; 肽类; 环; 哌嗪类;

机译：Glucose;Insulin;Liver;Peptides;Cyclic;Piperazines;Blood Glucose;C-Peptide;葡萄糖;胰岛素;肝;肽类;环;哌嗪类;

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1. Cyclo(His-Pro) augments the insulin response to oral glucose in rats. [J] . Mizumo H, Svec F, Prasad C, Life sciences . 1997,第6期

机译：Cyclo（His-Pro）增强大鼠对口服葡萄糖的胰岛素反应。
2. An insulin-related peptide expressed in 3T3L1 adipocytes is localized in GLUT4 vesicles and secreted in response to exogenous insulin, which augments the insulin-stimulated glucose uptake [J] . Nakamichi Y., Ohara-Imaizumi MO., Ishida H., Journal of Cell Science . 2003,第1期

机译：在3T3L1脂肪细胞中表达的胰岛素相关肽位于GLUT4囊泡中，并响应于外源胰岛素而分泌，从而增加了胰岛素刺激的葡萄糖摄取。
3. An insulin-related peptide expressed in 3T3L1 adipocytes is localized in GLUT4 vesicles and secreted in response to exogenous insulin, which augments the insulin-stimulated glucose uptake. [J] . Nakamichi Y, Ohara Imaizumi M, Ishida H, Journal of Cell Science . 2003,第Pta1期

机译：在3T3L1脂肪细胞中表达的胰岛素相关肽位于GLUT4囊泡中，并响应外源胰岛素而分泌，从而增加了胰岛素刺激的葡萄糖摄取。
4. Comparing glucose and insulin data from the two-hour oral glucose tolerance test in metabolic syndrome subjects and marathon runners [C] . Miguel Altuve, Gilberto Perpiñan, Erika Severeyn, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2016

机译：比较代谢综合征受试者和马拉松运动员两小时口服葡萄糖耐量试验的葡萄糖和胰岛素数据
5. Effects of hypohydration and oral or intravenous saline rehydration on glucose and insulin responses to carbohydrate feeding prior to exercise in the heat. [D] . Echegaray, Marcos Daniel. 1995

机译：缺水和口服或静脉内补液对热运动前葡萄糖和胰岛素对碳水化合物喂养的反应的影响。
6. The Effect of Fasting Duration on Baseline Blood Glucose Concentration Blood Insulin Concentration Glucose/Insulin Ratio Oral Sugar Test and Insulin Response Test Results in Horses [O] . F.R. Bertin, S.D. Taylor, A.W. Bianco, 2016

机译：空腹时间对马的基线血糖浓度血液胰岛素浓度葡萄糖/胰岛素比口服糖测试和胰岛素反应测试结果的影响
7. First-phase insulin response (FPIR) to intravenous glucose tolerance test (IVGTT), insulin sensitivity and long-term follow-up in ?- transfusion-dependent thalassemia (TDT) normoglycemic patients with reduced insulin secretion to oral glucose tolerance t [O] . Vincenzo De Sanctis 2021

机译：第一期胰岛素响应（FPIR）与静脉内葡萄糖耐量试验（IVGTT），胰岛素敏感性和长期随访？ - 输血依赖性血症（TDT）常规血糖患者减少胰岛素分泌到口腔葡萄糖耐受性

Cyclo(His-Pro) augments the insulin response to oral glucose in rats.

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