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首页> 外文期刊>Life sciences >Peribronchial lymphocyte activation in bleomycin-induced lung injury.
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Peribronchial lymphocyte activation in bleomycin-induced lung injury.

机译：博来霉素诱导的肺损伤中的支气管周围淋巴细胞活化。

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摘要

The role of lymphocytes in bleomycin (Bleo)-induced lung injury remains obscure. In normal hamsters, peribronchial lymphatic tissue (PBLT) has been found to contain a large population of T lymphocytes responsive to interleukin 2 (IL-2) but not to IL-4. Lung injury induced by a single intratracheal instillation of Bleo in hamsters has been ameliorated by cyclosporin A (CyA). In the present study, using this model, PBLT-derived lymphocyte function was explored for 28 days after Bleo instillation. Increase in PBLT lymphocytes occurred at five time points investigated, reaching highest values on day +7 (p < 0.0025). Cell proliferation in response to concanavalin A was enhanced, while IL-2 +/- the mitogen had no effect. In contrast to its inactivity in the normal hamster, in the Bleo-injured animal IL-4 alone induced T cell proliferation (p = 0.0077) on day +7. CyA therapy initially suppressed and delayed recovery of the number of lymphocytes and their activation. The results of this study suggest the existence of a vulnerable period in Bleo-induced lung injury and indicate that lymphocytes participate in the pathogenesis of the insult to the tissue. The unresponsiveness to IL-2 and the emergence of cellular response to IL-4 indicate immune deviation in PBLT-derived T cells.
机译：淋巴细胞在博来霉素（Bleo）诱导的肺损伤中的作用仍然不清楚。在正常仓鼠中，已发现支气管周淋巴组织（PBLT）包含大量对白介素2（IL-2）应答但对IL-4应答的T淋巴细胞。环孢菌素A（CyA）减轻了仓鼠一次气管内滴入Bleo引起的肺损伤。在本研究中，使用该模型，Bloo滴注后28天探索了PBLT衍生的淋巴细胞功能。在研究的五个时间点，PBLT淋巴细胞增加，在第7天达到最高值（p <0.0025）。响应刀豆球蛋白A的细胞增殖得到增强，而IL-2 +/-促分裂原则没有作用。与它在正常仓鼠中不起作用相反，在受损伤的动物中，单独的IL-4在第+7天诱导T细胞增殖（p = 0.0077）。 CyA疗法最初抑制并延迟了淋巴细胞数量及其活化的恢复。这项研究的结果表明，在Bloo诱发的肺损伤中存在脆弱时期，并表明淋巴细胞参与了对组织的损伤。对IL-2的无反应性和对IL-4的细胞反应的出现表明PBLT衍生的T细胞存在免疫偏离。

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