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首页> 外文期刊>Life sciences >Ontogeny of heart rate responses to exogenous melatonin in Muscovy duck and chicken embryos.
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Ontogeny of heart rate responses to exogenous melatonin in Muscovy duck and chicken embryos.

机译：番鸭和鸡胚胎中外源褪黑激素对心率反应的个体发育。

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摘要

One of the major physiological effects of melatonin is coupling the internal clock with different organ functions. Despite the long list of functional responses to melatonin discovered in the past, it has been unclear when responsiveness to melatonin develops during ontogeny. The aim of the present study was therefore to investigate in Muscovy duck and chicken embryos, when they start to exhibit heart rate (HR) changes to exogenous melatonin. HR was recorded continuously in Muscovy duck embryos from day 24 of incubation (D24) and in chicken embryos from D17 until hatching. Every day four doses of 10 microg melatonin were injected into each egg at 30 min intervals. In Muscovy duck embryos HR responses to melatonin were first observed on D25; from D27 all embryos responded. In all cases HR decreased immediately after the injection. HR deviation from baseline values and duration of decreased HR period increased during the experimental period. Chicken embryos showed similar responses as Muscovy ducks from D17 onwards; from D18 the response rate was 100%. On D19 dose-response data revealed a partial responsiveness to exogenous melatonin at doses of 0.1 to 1 ng and full responsiveness from 10 ng to 10 microg. The time of the first occurrence of HR responses to melatonin coincides with published results on the start of periodic pineal melatonin secretion. These data suggest that the output signal of the avian internal clock, periodic plasma melatonin fluctuations, could result in periodic cardiac function already prenatally in these two avian species.
机译：褪黑激素的主要生理作用之一是将内部时钟与不同器官功能耦合在一起。尽管过去发现了许多对褪黑激素的功能性反应，但尚不清楚个体发育过程中何时对褪黑素产生反应性。因此，本研究的目的是调查番鸭和鸡的胚胎，当它们开始表现出外源褪黑激素的心率（HR）变化时。从孵化的第24天（D24）开始连续在番鸭鸭子胚胎中记录HR，从孵化开始从D17开始在鸡胚中记录HR。每天以30分钟的间隔将四剂10微克褪黑素注射到每个鸡蛋中。在番鸭胚胎中，首先在D25上观察到了对褪黑激素的HR反应。从D27开始，所有胚胎都做出了反应。在所有情况下，注射后HR都会立即下降。在实验期间，HR偏离基线值和HR持续时间减少的持续时间增加。从D17开始，鸡胚表现出与番鸭相似的反应。从D18开始，回应率为100％。在D19上，剂量反应数据显示剂量为0.1到1 ng时，对外源褪黑素有部分反应，而从10 ng到10 microg则完全反应。首次对褪黑激素产生HR反应的时间与周期性松果体褪黑激素分泌开始时公布的结果相吻合。这些数据表明，禽类内部时钟的输出信号，周期性的血浆褪黑激素波动可能会导致这两种禽类在出生前已经出现周期性的心脏功能。

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