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首页> 外文期刊>Life sciences >Adenosine enhances glial glutamate efflux via A2a adenosine receptors.
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Adenosine enhances glial glutamate efflux via A2a adenosine receptors.

机译：腺苷通过A2a腺苷受体增强神经胶质谷氨酸外排。

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摘要

The present study investigated the effect of adenosine on glial glutamate efflux. Adenosine (from 1 nM to 100 microM) enhanced the release from cultured rat glial cells in a bell-shaped dose-responsive manner for the hippocampus and in a dose-dependent manner for the superior colliculus, and a similar increase was obtained with the A2a adenosine receptor agonist, 2-p-(2-carboxyethyl) phenethylamino-5'-N-ethylcarboxamidoadenosine hydrochloride (CGS21680), but not with the A1 adenosine receptor agonist, N6-cyclohexyladenosine (CHA). Adenosine and CGS21680 also enhanced glutamate efflux from Xenopus oocytes injected with the poly (A)+ mRNAs derived from cultured glial cells for the hippocampus and the superior colliculus together with and without the A2a adenosine receptor mRNA, but instead such increase was not found in oocytes expressing A2a adenosine receptors alone. The results of the present study thus suggest that adenosine enhances glutamate efflux from glial cells via A2a adenosine receptors, and this may represent a mechanism underlying the facilitatory action of adenosine on hippocampal and superior colliculus neurotransmissions.
机译：本研究调查了腺苷对神经胶质谷氨酸外排的影响。腺苷（从1 nM到100 microM）以钟形剂量响应方式增强海马的培养胶质细胞的释放，并以剂量​​依赖性方式增强上丘的胶质细胞的释放，A2a的增加类似腺苷受体激动剂2-p-（2-羧乙基）苯乙基氨基5'-N-乙基羧酰胺基腺苷盐酸盐（CGS21680），但不与A1腺苷受体激动剂N6-环己基腺苷（CHA）结合使用。腺苷和CGS21680还增强了非洲爪蟾卵母细胞的谷氨酸外流，注射了来自培养的海马和上丘神经胶质细胞的poly（A）+ mRNA，以及是否存在A2a腺苷受体mRNA，但在卵母细胞中未发现这种增加仅表达A2a腺苷受体。因此，本研究的结果表明，腺苷通过A2a腺苷受体增强神经胶质细胞的谷氨酸外排，这可能代表了腺苷对海马和上丘神经传递的促进作用的机制。

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