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首页> 外文期刊>Life sciences >Effect of beta-Carotene on the development of the solid Ehrlich tumor in mice.
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Effect of beta-Carotene on the development of the solid Ehrlich tumor in mice.

机译：β-胡萝卜素对小鼠实体Ehrlich肿瘤发展的影响。

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摘要

The effect of beta-Carotene on the development of the solid Ehrlich tumor in BALB/c mice was investigated. Male mice received orally, on alternate days, three different doses of beta-Carotene (1, 3.5 or 7 mg/100 g) or corn oil as the control. This protocol started 14 days before tumor inoculation (1.75 x 10(5) cells) into mouse footpad and lasted until 10 days after. The tumor growth was evaluated by daily measurement of the footpad thickness, and the tumor mass was evaluated morphometrically. The proliferation rate of tumor was investigated by counting PCNA (proliferating cell nuclear antigen) positive nuclei in the 10th day of the tumor development. Histopathological examination of the lymphoid tissue: thymus, spleen and popliteal lymph node were also performed. beta-Carotene treatment, at dose 3.5 mg/100 g, increased the tumor growth, proliferative rate and the relative weight of popliteal lymph nodes, showing up an adverse effect only when this intermediate dose was used. No effects were obtained when the smaller (1,0 mg/100 g) or the higher (7.0 mg/100 g) doses were used. These results suggest that depending on the dose, beta-Carotene may determine an undesirable effect upon the tumor growth. This should be taken into account in chemopreventive experiments and human applications.
机译：研究了β-胡萝卜素对BALB / c小鼠实体Ehrlich肿瘤发展的影响。雄性小鼠隔天口服三种不同剂量的β-胡萝卜素（1、3.5或7 mg / 100 g）或玉米油作为对照。该方案开始于肿瘤接种（1.75 x 10（5）细胞）到小鼠足垫之前的14天，一直持续到之后的10天。通过每天测量脚垫厚度来评估肿瘤的生长，并通过形态计量学评估肿瘤块。通过在肿瘤发展的第10天中计数PCNA（增殖细胞核抗原）阳性核来研究肿瘤的增殖速率。淋巴组织的组织病理学检查：胸腺，脾脏和pop神经淋巴结也进行了检查。 β-胡萝卜素的剂量为3.5 mg / 100 g，可增加肿瘤的生长，增殖速率和rate淋巴结的相对重量，仅在使用该中间剂量时才显示出不良反应。当使用较小剂量（1,0 mg / 100 g）或较高剂量（7.0 mg / 100 g）时，未获得任何效果。这些结果表明，取决于剂量，β-胡萝卜素可能会确定对肿瘤生长的不良影响。在化学预防实验和人体应用中应考虑到这一点。

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