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首页> 外文期刊>Life sciences >Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats.
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Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats.

机译：日粮白藜芦醇的降脂作用，在患有肝癌的大鼠中，是葡萄和红酒中的植物抗毒素。

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摘要

Resveratrol is an antioxidant present in grapes and their related products. We investigated whether dietary resveratrol could inhibit the proliferation and metastasis of tumors and hyperlipidemia in Donryu rats subcutaneously implanted with an ascites hepatoma cell line of AH109A. By feeding 10 or 50 ppm resveratrol in the diet to hepatoma-bearing rats for 20 days, solid tumor growth and metastasis tended to be suppressed dose-dependently. Resveratrol (50 ppm) significantly suppressed the serum lipid peroxide level, indicating its antioxidative properties or those of its metabolite(s) in vivo. Resveratrol dose-dependently suppressed both the serum triglyceride and very-low-density lipoprotein + low-density lipoprotein (VLDL + LDL)-cholesterol levels. The hypocholesterolemic action of resveratrol is attributed, at least in part, to an increased excretion of neutral sterols and bile acids into feces. These results suggest that dietary resveratrol is hypolipidemic with a tendency for anti-tumor-growth andanti-metastasis effects in hepatoma-bearing rats.
机译：白藜芦醇是葡萄及其相关产品中的抗氧化剂。我们研究了日粮白藜芦醇是否可以抑制AH109A腹水肝细胞瘤皮下植入的Donryu大鼠的增殖和转移以及高脂血症。通过给饮食中的肝癌大鼠饲喂10或50 ppm白藜芦醇20天，实体瘤的生长和转移趋于剂量依赖性地被抑制。白藜芦醇（50 ppm）可显着抑制血清脂质过氧化物水平，表明其抗氧化特性或其体内代谢产物的抗氧化特性。白藜芦醇剂量依赖性地抑制血清甘油三酸酯和极低密度脂蛋白+低密度脂蛋白（VLDL + LDL）-胆固醇水平。白藜芦醇的降胆固醇作用至少部分归因于中性固醇和胆汁酸排泄到粪便中。这些结果表明，饮食中的白藜芦醇具有降血脂作用，在具有肝癌的大鼠中具有抗肿瘤生长和抗转移作用的趋势。

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