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首页> 外文期刊>Life sciences >Vitamin D receptor gene polymorphism is associated with chronic periodontitis.
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Vitamin D receptor gene polymorphism is associated with chronic periodontitis.

机译：维生素D受体基因多态性与慢性牙周炎有关。

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Chronic periodontitis (CP) is caused by enhanced resorption of the alveolar bone supporting the teeth and is associated with intraoral inflammation after infection with certain bacteria. The VDR gene polymorphism was reported recently to be deeply related to the occurrence of tuberculosis and infection of chronic hepatitis B virus. This may be interpreted to indicate a close relationship between VDR gene polymorphism and the immunological action, because vitamin D activates monocytes, stimulates cell-mediated immunity, and suppresses lymphocyte proliferation. The purpose of the present study was to clarify whether polymorphisms in VDR gene exons are associated with the incidence of CP. A case-controlled study was performed on a group of 168 unrelated Japanese subjects whose ages ranged from 35 to 65 years. The Taq I polymorphism in the VDR gene was found to be associated significantly with CP (X(2) = 4.48, P = 0.034). We performed multiple logistic regression analyses on the TT genotype, which was found to be associated with CP, and on well-recognized risk factors, smoking and diabetes. The odds ratio (OR) for the genotype (TT/Tt) was 2.73 (95% CI 1.11-6.68, P = 0.028), being larger than the unadjusted value. This indicates that the VDR gene polymorphism (TT genotype) is a risk factor for CP, independently of smoking and diabetes.
机译：慢性牙周炎（CP）是由支持牙齿的牙槽骨吸收增强引起的，并与某些细菌感染后的口腔内炎症有关。最近报道了VDR基因多态性与结核病的发生和慢性乙型肝炎病毒的感染密切相关。这可以解释为表明VDR基因多态性与免疫作用之间的密切关系，因为维生素D激活单核细胞，刺激细胞介导的免疫，并抑制淋巴细胞增殖。本研究的目的是阐明VDR基因外显子的多态性是否与CP的发生有关。对一组168名年龄在35至65岁之间的日本无关受试者进行了病例对照研究。发现VDR基因中的Taq I多态性与CP显着相关（X（2）= 4.48，P = 0.034）。我们对被发现与CP相关的TT基因型以及公认的危险因素，吸烟和糖尿病进行了多项逻辑回归分析。基因型（TT / Tt）的比值比（OR）为2.73（95％CI 1.11-6.68，P = 0.028），大于未调整值。这表明VDR基因多态性（TT基因型）是CP的危险因素，与吸烟和糖尿病无关。

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