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首页> 外文期刊>Life sciences >Effects of irbesartan and bosentan on the blood pressure and adrenal zona glomerulosa function in heterozygous transgenic TGR(mREN2)27 rats.
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Effects of irbesartan and bosentan on the blood pressure and adrenal zona glomerulosa function in heterozygous transgenic TGR(mREN2)27 rats.

机译：厄贝沙坦和波生坦对杂合转基因TGR（mREN2）27大鼠的血压和肾上腺小球功能的影响。

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摘要

The role of angiotensin-II (Ang-II) and endothelin-1 (ET-1) in the development of hypertension and zona glomerulosa (ZG) hyperfunction in the transgenic rat strain TGR[mREN2]27 (TGR) has been investigated. Male heterozygous TGR were given per os for 4 weeks the Ang-II ATI receptor antagonist irbesartan (50 mg/kg x day) or the mixed ETA/ETB receptor antagonist bosentan (100 mg/kg x day). A group of TGR received a placebo gavage. Irbesartan lowered blood pressure (BP), while bosentan was ineffective. Conversely, both antagonists decreased plasma aldosterone concentration, the volume of ZG and its parenchymal cells, and in vitro aldosterone secretion by capsule-ZG preparations. Collectively, our results allow us to conclude that (i) only Ang-II is involved in the genesis of hypertension in TGR, while both endogenous Ang-II and ET-1 play a role in the genesis of ZG hyperfunction; and (ii) hyperaldosteronism does not contribute significantly to the development of hypertension in TGR.
机译：研究了转基因大鼠TGR [mREN2] 27（TGR）的血管紧张素-II（Ang-II）和内皮素-1（ET-1）在高血压和肾小球性肾炎（ZG）功能亢进中的作用。雄性杂合TGR口服给予Ang-II ATI受体拮抗剂厄贝沙坦（50 mg / kg x天）或混合的ETA / ETB受体拮抗剂波生坦（100 mg / kg x天），持续4周。一组TGR接受了安慰剂管饲。厄贝沙坦降低了血压（BP），而波生坦无效。相反，两种拮抗剂均会降低血浆醛固酮浓度，ZG及其实质细胞的体积以及胶囊ZG制剂的体外醛固酮分泌。总的来说，我们的结果使我们得出以下结论：（i）只有Ang-II参与了TGR高血压的发生，而内源性Ang-II和ET-1都在ZG功能亢进的发生中起作用; （ii）醛固酮增多症对TGR高血压的发展没有明显贡献。

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