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Stress, anxiety and peripheral benzodiazepine receptor mRNA levels in human lymphocytes

机译:人淋巴细胞中的应激,焦虑和外周苯二氮卓受体mRNA水平

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Peripheral benzodiazepine receptor (PBR) mRNA levels were measured in lymphocytes obtained from a cohort of university students and clinically diagnosed anxious patients. The average level of PER mRNA was decreased in anxious patients compared to a control group. This data confirms previously published results, but it also indicates that PER mRNA levels cannot be used as a sole diagnostic measure of anxiety because the range of the individual PER mRNA levels of the anxious group overlapped the range of the PER mRNA levels of the control group, PER mRNA levels in students following academic examinations were increased in some individuals and decreased in others. In the same cohort of students individual levels of cortisol and prolactin were predominantly increased and decreased respectively. There was no correlation between the individual changes in the hormone levels or PER mRNA, which suggests that each of these parameters is affected by different environmental and physiological factors. Lymphocyte PER mRNA measurement is a useful additional methodology for studying human stress responses however, its use in clinical studies would require the elucidation of PBR's physiological role. (C) 2000 Elsevier Science Inc. All rights reserved. [References: 33]
机译:在从一群大学生和临床诊断出的焦虑症患者的淋巴细胞中测量了外周苯二氮卓类受体(PBR)mRNA的水平。与对照组相比,焦虑患者的PER mRNA平均水平降低。该数据证实了先前发表的结果,但也表明PER mRNA水平不能用作焦虑症的唯一诊断手段,因为焦虑组的各个PER mRNA水平范围与对照组的PER mRNA水平范围重叠,学术考试后学生的PER mRNA水平在某些人中有所增加,而在其他人中则有所下降。在同一批学生中,皮质醇和催乳素的各自水平分别显着升高和降低。激素水平或PER mRNA的个体变化之间没有相关性,这表明这些参数中的每一个均受不同的环境和生理因素影响。淋巴细胞PER mRNA的测量是研究人类压力反应的一种有用的其他方法,但是,在临床研究中使用它需要阐明PBR的生理作用。 (C)2000 Elsevier Science Inc.保留所有权利。 [参考:33]

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