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首页> 外文期刊>Life sciences >Anticonvulsive and free radical scavenging activities of vanillyl alcohol in ferric chloride-induced epileptic seizures in Sprague-Dawley rats.
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Anticonvulsive and free radical scavenging activities of vanillyl alcohol in ferric chloride-induced epileptic seizures in Sprague-Dawley rats.

机译：香草醇在氯化铁诱导的Sprague-Dawley大鼠癫痫发作中的抗惊厥和自由基清除活性。

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摘要

Vanillyl alcohol (VA) is a component of Gastrodia elata Bl. (GE), which is a traditional Chinese herb widely used to treat convulsive disorders or dizziness. This study examined the role of VA in the anticonvulsive properties of GE in a Sprague-Dawley rat model of epilepsy. The anticonvulsive and free radical scavenging activities of VA were examined after intracortical injection of ferric chloride (100 mM, 8 microl) to induce epileptic seizures. These seizures were verified by behavioral observations and electroencephalographic (EEG) and electromyographic (EMG) recordings. Ferric chloride injection resulted in increased lipid peroxide levels in the ipsilateral and contralateral cerebral cortex, and increased luminol-chemiluminescence (CL) and lucigenin-CL counts in the peripheral blood. Intraperitoneal injection (i.p.) of VA (200 mg/kg or 100 mg/kg) or phenytoin 10 mg/kg prior to ferric chloride administration significantly inhibited wet dog shakes (WDS) and lipid peroxide levels in the bilateral cerebral cortex. VA 200 mg/kg also significantly reduced luminol-CL and lucigenin-CL counts in the peripheral blood, but no significant effect was observed following administration of VA 100 mg/kg or phenytoin. These data indicate that VA has both anticonvulsive and suppressive effects on seizures and lipid peroxidation induced by ferric chloride in rats. Data from the present study also demonstrate that VA has free radical scavenging activities, which may be responsible for its anticonvulsive propertics. This finding is consistent with the results from previous studies that generation of superoxide radical evoked by injection of iron salt into rat brain plays a critical role in ferric chloride-induced seizures. In addition, the results of the present study suggest that the anticonvulsive effect of GE may be attributable, at least in part, to its VA component.
机译：香兰醇（VA）是天麻的组成部分。 （GE），这是一种传统中草药，广泛用于治疗惊厥性疾病或头晕。这项研究检查了VA在Sprague-Dawley大鼠癫痫模型中的抗惊厥特性中的作用。皮层内注射氯化铁（100 mM，8 microl）诱发癫痫发作后，检查VA的抗惊厥和清除自由基的活性。这些癫痫发作通过行为观察以及脑电图（EEG）和肌电图（EMG）记录进行了验证。氯化铁注射导致同侧和对侧大脑皮层脂质过氧化物水平增加，外周血中鲁米诺化学发光（CL）和光泽素-CL计数增加。在氯化铁给药前腹膜内注射（i.p.）VA（200 mg / kg或100 mg / kg）或苯妥英10 mg / kg可以显着抑制双侧大脑皮层的湿狗摇动（WDS）和脂质过氧化物水平。 VA 200 mg / kg还可显着降低外周血中的Luminol-CL和Lucigenin-CL计数，但在服用VA 100 mg / kg或苯妥英钠后未观察到明显的作用。这些数据表明，VA对大鼠的癫痫发作和氯化铁引起的脂质过氧化具有抗惊厥和抑制作用。来自本研究的数据还表明VA具有自由基清除活性，这可能是其抗惊厥特性的原因。这一发现与以前的研究结果一致，即通过向大鼠脑内注射铁盐诱发的超氧化物自由基的产生在氯化铁诱发的癫痫发作中起关键作用。此外，本研究的结果表明，GE的抗惊厥作用可能至少部分归因于其VA成分。

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