• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Effect of systemic lupus erythematosus (SLE) treatment drugs on GI-101A breast tumor cell growth.
【24h】

Effect of systemic lupus erythematosus (SLE) treatment drugs on GI-101A breast tumor cell growth.

机译：系统性红斑狼疮（SLE）治疗药物对GI-101A乳腺肿瘤细胞生长的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effect of systemic lupus erythematosus (SLE) treatment drugs on PKC (protein kinase C) activity and cell growth was studied using GI-101A breast tumor cells. Both hydroxychloroquine (HCQ) and prednisone treatments significantly increased the PKC activity in GI-101A cells after 60 min. Treatment of cells with a combination of HCQ/prednisone also produced the highest increase in PKC activity following 60 min incubation. When the GI-101A cells were treated with the same drugs, HCQ (10 ng/ml) prednisone (10 ng/ml) and HCQ/prednisone combination (10 ng/ml of each), for 72 hr the total PKC activity in the cells was significantly elevated and consequently the GI-101A cell growth was stimulated. As a result of drug induced cell growth stimulation the total number of cells in the treatment groups increased significantly compared to the non-treated controls. Interestingly HCQ and prednisone treatment induced cell growths were completely blocked by PKC specific inhibitor chelerythrine (50 microM). Our results suggest that HCQ and prednisone treatment can induce GI-101A cell growth via activating PKC.
机译：使用GI-101A乳腺肿瘤细胞研究了系统性红斑狼疮（SLE）治疗药物对PKC（蛋白激酶C）活性和细胞生长的影响。 60分钟后，羟氯喹（HCQ）和强的松治疗均显着增加GI-101A细胞的PKC活性。孵育60分钟后，用HCQ /泼尼松联合处理细胞也可使PKC活性最高。当GI-101A细胞用相同的药物处理时，HCQ（10 ng / ml）泼尼松（10 ng / ml）和HCQ /泼尼松组合（每种10 ng / ml）处理72小时，总PKC活性细胞显着升高，因此刺激了GI-101A细胞的生长。作为药物诱导的细胞生长刺激的结果，与未治疗的对照相比，治疗组中的细胞总数显着增加。有趣的是，HCQ和泼尼松治疗诱导的细胞生长被PKC特异性抑制剂白屈菜红碱（50 microM）完全阻断。我们的结果表明，HCQ和泼尼松治疗可以通过激活PKC诱导GI-101A细胞生长。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号