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首页> 外文期刊>Life sciences >Increased ACTH and cortisol secretion after interleukin-alpha injection in the common marmoset (Callithrix jacchus jacchus).
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Increased ACTH and cortisol secretion after interleukin-alpha injection in the common marmoset (Callithrix jacchus jacchus).

机译：普通mar猴（Callithrix jacchus jacchus）注射白介素-α后，ACTH和皮质醇分泌增加。

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摘要

We have studied the effect of intravenous injection of interleukin-1 (dose range: from 0.25 to 4.5 microg/kg of body weight) on plasma ACTH and cortisol levels in the marmoset, a primate paradygm of peripheral glucocorticoid resistance. Blood sampling were collected and body temperature recorded 0, 15, 30, 60, 120, 180, 240 and 300 min after injection. Interleukin-1 stimulated secretion of ACTH in a dose-dependent fashion. Maximal secretion occurred 120 min after injection, and lasted up to 240 min. Plasma ACTH levels returned to baseline 300 min after interleukin-1 injection. Plasma cortisol levels were related to ACTH levels. Body temperature elevation, which occurred 10-15 min after injection was dose-dependent, and lasted 3 h. Results suggest that the pyrogenic effect of interleukin is associated, in the marmoset, with integrated activation of the hypothalamic-pituitary-adrenal axis. In light of the proneness of marmosets to hyperimmune disorders, our data are consistent with the hypothesized central biological role of IL-1, as well as the pathophysiological relevance of the neuro-endocrine-immune cross-talk during the acute phase response.
机译：我们已经研究了静脉注射白细胞介素-1（剂量范围：0.25至4.5微克/千克体重）对，猴（外周缘糖皮质激素抵抗的灵长类动物天堂）中血浆ACTH和皮质醇水平的影响。注射后收集血样并记录0、15、30、60、120、180、240和300分钟的体温。白介素-1以剂量依赖性方式刺激ACTH分泌。注射后120分钟发生最大分泌，持续长达240分钟。注射白介素1 300分钟后血浆ACTH水平恢复到基线。血浆皮质醇水平与ACTH水平有关。注射后10-15分钟发生的体温升高是剂量依赖性的，持续3小时。结果表明，在the猴中，白介素的热原作用与下丘脑-垂体-肾上腺轴的整合激活有关。鉴于mar猴容易出现超免疫性疾病，我们的数据与假设的IL-1的中心生物学作用以及急性期反应期间神经内分泌免疫串扰的病理生理相关性是一致的。

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