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Physical consequences of schizophrenia and its treatment. The metabolic syndrome.

机译：精神分裂症的物理后果及其治疗。代谢综合症。

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Schizophrenia is a life shortening illness. Unnatural causes and natural causes are put forward as reasons for this excess mortality. In terms of the latter, a host of different physical disorders occur with increased frequency in schizophrenia. When taken together, some of these illnesses such as type 2 diabetes mellitus and cardiovascular disorders constitute the Metabolic Syndrome; a characteristic phenotype of those with this syndrome is excessive visceral fat distribution. The exact reasons why this particular syndrome occurs in schizophrenia is as yet unclear though factors such as life style, poor diet and lack of exercise may contribute to it's development. Alternatively, overactivity of the hypothalamic-pituitary-adrenal axis leading to hypercortisolaemia can also result in excessive visceral fat accumulation. This minireview aims to explore the potential role of these issues and medication in terms of the increased morbidity and mortality observed in schizophrenia.
机译：精神分裂症是缩短寿命的疾病。提出非自然原因和自然原因是造成这种过度死亡的原因。就后者而言，精神分裂症中会发生许多不同的身体疾病，且发生频率增加。综合起来，其中的某些疾病（如2型糖尿病和心血管疾病）构成了代谢综合征。这种综合征的特征表型是内脏脂肪分布过多。尽管诸如生活方式，不良饮食和缺乏运动之类的因素可能会导致精神分裂症发生这种特定综合征，但尚不清楚其确切原因。或者，下丘脑-垂体-肾上腺轴过度活动导致皮质醇过多，也会导致内脏脂肪过多积聚。这项小型审查旨在探讨精神分裂症中发病率和死亡率增加方面这些问题和药物的潜在作用。

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