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首页> 外文期刊>Life sciences >Evidence of relaxant effect of omeprazole in rabbit corpus cavernosum in vitro.
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Evidence of relaxant effect of omeprazole in rabbit corpus cavernosum in vitro.

机译：奥美拉唑对兔海绵体体外舒张作用的证据。

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摘要

The present experiments were designed to investigate the effects of omeprazole, a H(+)-K+ ATPase inhibitor, on corporal smooth muscle tone in vitro. All spontaneous contractile activity in the corpus cavernosum was blocked following omeprazole (0.1 mM-1 mM) administration. However atropine (1 microM), Nw-nitro L-arginine methyl ester (L-NAME, 30 microM) or indomethacin (10 microM) did not affect the spontaneous contraction. Omeprazole (10 microM-1 mM) concentration-dependently induced relaxation in corporal smooth muscle precontracted with 10 microM phenylephrine or 80 mM KCl. Pretreatment of corporal tissue with L-NAME (30 microM), indomethacin (10 microM), ammonium chloride (7.5 mM), sodium acetate (7.5 mM), tetraethyl ammonium chloride (0.5 mM) or glibenclamide (1 microM) had no effect on the omeprazole induced relaxant responses. Nimodipine, an L-type Ca++ channel blocker, relaxed corporal strips precontracted with 80 mM KCl. Collectively, these results indicate that the inhibition of spontaneous contraction and the relaxation of precontracted corporal smooth muscle by omeprazole is probably mediated by the blockade of calcium channels. Further work is needed to determine the cellular mechanism(s) of action by which omeprazole acts on corpus cavernosum smooth muscle.
机译：本实验旨在研究奥美拉唑（一种H（+）-K + ATPase抑制剂）对体外体平滑肌音调的影响。奥美拉唑（0.1 mM-1 mM）给药后，海绵体中所有自发的收缩活性均被阻断。但是，阿托品（1 microM），Nw-硝基L-精氨酸甲酯（L-NAME，30 microM）或消炎痛（10 microM）不会影响自发性收缩。奥美拉唑（10 microM-1 mM）浓度依赖性地诱导与10 microM苯肾上腺素或80 mM KCl预收缩的身体平滑肌松弛。用L-NAME（30 microM），消炎痛（10 microM），氯化铵（7.5 mM），乙酸钠（7.5 mM），四乙基氯化铵（0.5 mM）或格列本脲（1 microM）预处理体组织奥美拉唑引起的松弛反应。尼莫地平是一种L型Ca ++通道阻滞剂，可松弛的身体条带预先与80 mM KCl缔合。总体而言，这些结果表明，奥美拉唑对自发性收缩的抑制和预收缩体平滑肌的松弛可能是由钙通道的阻断介导的。需要进一步的工作来确定奥美拉唑对海绵体平滑肌起作用的细胞作用机制。

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