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首页> 外文期刊>Life sciences >Exploration of the awakening cortisol response in relation to diurnal cortisol secretory activity.
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Exploration of the awakening cortisol response in relation to diurnal cortisol secretory activity.

机译：探索与每日皮质醇分泌活动有关的皮质醇唤醒反应。

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Adrenocortical activity can be assessed by measurement of free cortisol in saliva. Cortisol status has important health implications in both physical and psychological terms. Assessment of cortisol status is complicated by the marked diurnal cortisol cycle. This cycle is characterised by an increase in secretory activity following awakening to achieve the morning acrophase. Thereafter it falls with a declining trend over the remainder of the day. For between subject studies the timing of sampling in relation to this cycle is an important consideration. We report a comprehensive study of the diurnal free cortisol cycle designed to analyse its components and to investigate their reliability and inter-relatedness. We instructed 42 healthy volunteers to collect saliva samples at home on two consecutive days. On each day the first sample was collected immediately upon awakening, followed by a further three samples at 15-minute intervals which collectively comprised the "awakening samples". A further four sample's were collected through the day at 3-hour intervals, all synchronized to awakening time. The cortisol response to awakening was calculated in two ways. Overall cortisol production in the first 45 minutes after awakening was calculated as area under the cortisol curve with reference to zero (AUC). The dynamic of the cortisol response to awakening was calculated as area under the cortisol response curve (AURC) with reference to the first awakening sample. In addition the underlying cortisol secretory activity was assessed based upon the diurnal three-hourly samples. All three parameters of adrenocortical activity showed reasonable stability across the two sampling days indicating all were reliable indexes of trait characteristic. AUC was representative of underlying diurnal activity but AURC was not. Measurement at any time point, 3, 6, 9 or 12 hours post-awakening was representative of the underlying 12-hour diurnal activity.
机译：可以通过测量唾液中的游离皮质醇来评估肾上腺皮质活动。皮质醇状态在身体和心理方面都具有重要的健康意义。皮质醇状态的评估因昼夜皮质醇循环明显而复杂。该循环的特征在于唤醒后达到早晨顶生期后分泌活性增加。此后，它在一天的剩余时间内呈下降趋势。对于主题研究而言，与该周期有关的采样时间是一个重要的考虑因素。我们报告了日间游离皮质醇循环的全面研究，旨在分析其成分并调查其可靠性和相互关系。我们指示42名健康志愿者连续两天在家中收集唾液样本。每天在唤醒后立即收集第一个样品，然后以15分钟为间隔再收集另外三个样品，这些样品统称为“唤醒样品”。全天以3小时为间隔收集另外四个样本，所有样本均与唤醒时间同步。皮质醇对苏醒的反应是通过两种方法计算的。醒后最初45分钟的总皮质醇生成量以皮质醇曲线下的面积（相对于零（AUC））计算。参照第一个觉醒样品，将皮质醇对觉醒的响应的动态计算为皮质醇反应曲线（AURC）下的面积。另外，基于每日三小时的样品评估潜在的皮质醇分泌活性。肾上腺皮质活动的所有三个参数在两个采样日内显示出合理的稳定性，表明它们都是性状特征的可靠指标。 AUC代表潜在的昼夜活动，但AURC则不行。觉醒后3、6、9或12小时的任何时间点的测量值都代表了潜在的12小时昼夜活动。

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