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首页> 外文期刊>Life sciences >Renal glucose reabsorption during hypertonic glucose infusion in female streptozotocin-induced diabetic rats
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Renal glucose reabsorption during hypertonic glucose infusion in female streptozotocin-induced diabetic rats

机译：雌性链脲佐菌素诱导的糖尿病大鼠高渗葡萄糖输注过程中肾脏对葡萄糖的重吸收

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Information regarding the renal glucose transport capacity in diabetes mellitus is limited. These data are needed because two weeks following injection of streptozotocin (STZ), mRNA and protein levels of the glucose transporter, GLUT2, are upregulated in the proximal tubule of the rat. Therefore, we measured renal glucose transport and GLUT2 protein levels in female control rats, and in rats one (STZ-1), two (STZ-2), and three weeks (STZ-3) after STZ injection (65 mg kg(-1), ip). Progressive amounts of glucose were infused into anesthetized rats via the femoral Vein and renal clearances collected. The amount of glucose reabsorbed, factored by the glomerular filtration rate (GFR) was significantly greater in STZ-3 rats compared with all other groups. In addition, the amount of glucose reabsorbed factored by the amount of glucose filtered was decreased in STZ-1 and STZ-2 compared with controls but was increased in STZ-3. By contrast, renal GLUT2 levels were elevated in all the STZ-treated rats. These data suggest that other factors, functioning either in conjunction with or independent of GLUT2, are required to support an elevated renal glucose transport capacity. (C) 2001 Elsevier Science Inc. All rights reserved. [References: 29]
机译：关于糖尿病中肾葡萄糖转运能力的信息是有限的。需要这些数据是因为注射链脲佐菌素（STZ）两周后，大鼠近端小管中的葡萄糖转运蛋白GLUT2的mRNA和蛋白水平上调。因此，我们测量了雌性对照大鼠以及注射STZ（65 mg kg（-）的大鼠（STZ-1），两只（STZ-2）和三周（STZ-3）的肾脏葡萄糖转运和GLUT2蛋白水平。 1），ip）。通过股静脉将渐进量的葡萄糖输注到麻醉的大鼠中并收集肾清除率。与所有其他组相比，STZ-3大鼠的肾小球滤过率（GFR）导致的重吸收葡萄糖量显着增加。另外，与对照相比，在STZ-1和STZ-2中，因过滤的葡萄糖量而引起的再吸收的葡萄糖量减少，但在STZ-3中增加。相比之下，所有经STZ治疗的大鼠的肾脏GLUT2水平均升高。这些数据表明，需要其他与​​GLUT2结合或独立运作的因素来支持升高的肾脏葡萄糖转运能力。 （C）2001 Elsevier Science Inc.保留所有权利。 [参考：29]

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