• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >AN EXAMINATION OF THE CENTRAL SITES OF ACTION OF CANNABINOID-INDUCED ANTINOCICEPTION IN THE RAT
【24h】

AN EXAMINATION OF THE CENTRAL SITES OF ACTION OF CANNABINOID-INDUCED ANTINOCICEPTION IN THE RAT

机译：对大麻素诱导的大鼠止痛作用的中央部位的检查

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Microinjections of low doses of the potent and selective cannabinoids WIN 55,212-2 and CP 55,940 into the lateral ventricle produce long-lasting reduction in sensitivity to noxious thermal stimuli (1). To determine the central distribution of ventricularly administered WIN55,212-2, we microinjected an analgesic dose of the drug with [H-3]WIN55,212-2. At the peak time of antinociception, the radiolabeled drug was confined to periventricular sites throughout the brain. The contribution of particular periventricular structures to the antinociceptive effect was evaluated using intracerebral microinjection techniques and the tail-flick test. Guide cannulae were implanted above the following periventricular structures: the medial septal area, lateral habenlua, perihypothalamic area, arcuate nucleus of the hypothalamus, dorsal raphe nucleus and the dorsolateral and ventrolateral aspects of the periaqueductal gray. Microinjections of WIN55,212-2 (5 mu g/0.5 mu l) into the medial septal area, lateral habenula, perihypothalamic area, arcuate nucleus, and ventrolateral periaqueductal gray did not significantly affect tail-flick latencies. By contrast, microinjections of WIN55,212-2 into the dorsolateral periaqueductal gray and the dorsal raphe significantly elevated tail-flick latencies. The results of this study indicate that at least two periventricular structures within the brain are involved in cannabinoid antinociception. [References: 39]
机译：低剂量强效和选择性大麻素WIN 55,212-2和CP 55,940微量注射到侧脑室会导致对有害热刺激的敏感性长期持续降低（1）。为了确定心室给药的WIN55,212-2的中心分布，我们将[H-3] WIN55,212-2的镇痛剂微注射到该药物中。在抗伤害感受的高峰时间，放射性标记的药物被限制在整个大脑的脑室周围。使用脑内显微注射技术和甩尾试验评估特定的脑室周围结构对镇痛作用的贡献。引导插管被植入以下心室周围结构上方：内侧中隔区，外侧汉本卢，下丘脑周围区，下丘脑弓状核，背ra核以及导水管周围灰色的背外侧和腹侧。将WIN55,212-2（5μg / 0.5μl）微量注射到内侧中隔区，外侧ha，下丘脑周围区，弓形核和腹外侧导水管周围的灰色区域，不会显着影响甩尾潜伏期。相比之下，将WIN55,212-2微注射到背外侧导水管周围的灰色和背沟中会显着提高甩尾潜伏期。这项研究的结果表明，大脑中至少有两个脑室周围结构参与了大麻素的镇痛作用。 [参考：39]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号