PROTEIN KINASES AND PHOSPHATASES MODULATE C-FOS EXPRESSION IN RAT HEPATOCYTES - EFFECTS OF ANGIOTENSIN II AND PHORBOL MYRISTATE ACETATE

Gonzalezespinosa C.; Garciasainz JA.

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PROTEIN KINASES AND PHOSPHATASES MODULATE C-FOS EXPRESSION IN RAT HEPATOCYTES - EFFECTS OF ANGIOTENSIN II AND PHORBOL MYRISTATE ACETATE

机译：蛋白激酶和磷酸酶调节大鼠肝细胞中C-FOS的表达-血管紧张素II和醋酸乙酰苯酚的作用

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In isolated rat hepatocytes angiotensin II and phorbol 12-myristate 13-acetate(PMA) induce the expression of c-fos. We studied the possible transduction pathway(s) involved in this effect using inhibitors of serine-threonine and tyrosine protein kinases. Calphostin and staurosporine, inhibitors of protein kinase C and other serine-threonine protein kinases, block in a dose-dependent manner the effect of angiotensin II and PMA. Interestingly, genistein also blocks the induction of this proto-oncogene, suggesting a role for tyrosine protein kinases. Inhibitors of serine-threonine protein phosphatases, such as okadaic acid, microcystin LR and calyculin also induce c-fos expression. These data suggest that protein phosphatases exert a tonic inhibitory control of c-fos expression. The effect of these phosphatase inhibitors were not blocked by staurosporine, calphostin or genistein. Our results suggest that the expression of c-fos in rat hepatocytes is regulated by complex phosphorylation-dephosphorytation cascade(s) probably involving serine/threonine and tyrosine protein kinase and protein phosphatase activities. [References: 38]

机译：在分离的大鼠肝细胞中，血管紧张素II和佛波醇12-肉豆蔻酸酯13-乙酸酯（PMA）诱导c-fos的表达。我们使用丝氨酸-苏氨酸和酪氨酸蛋白激酶抑制剂研究了可能与这种作用有关的转导途径。 Calphostin和staurosporine，蛋白激酶C和其他丝氨酸-苏氨酸蛋白激酶的抑制剂，以剂量依赖的方式阻断血管紧张素II和PMA的作用。有趣的是，染料木黄酮还可以阻止这种原癌基因的诱导，提示酪氨酸蛋白激酶的作用。丝氨酸-苏氨酸蛋白磷酸酶的抑制剂，例如冈田酸，微囊藻毒素LR和钙霉素也诱导c-fos表达。这些数据表明蛋白质磷酸酶发挥了对c-fos表达的抑制作用。这些磷酸酶抑制剂的作用不会被星形孢菌素，钙磷蛋白或染料木黄酮所阻断。我们的结果表明，大鼠肝细胞中c-fos的表达受复杂的磷酸化-去磷酸化级联反应的调节，可能涉及丝氨酸/苏氨酸和酪氨酸蛋白激酶以及蛋白磷酸酶的活性。 [参考：38]

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《Life sciences》 |1995年第10期|共6页
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Gonzalezespinosa C.; Garciasainz JA.;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Protein kinase; C-fos expression; Hepatocytes; Angiotensin ii; Phorbol myristate acetate; Okadaic acid; Phosphoinositide turnover; Gene-expression; Calcium; Stimulation; Inhibitor; Cells; Phosphorylation; Transcription; Liver;

机译：蛋白激酶;C-fos表达;肝细胞;血管紧张素ii;肉豆蔻酸乙酸酯;冈田酸;磷酸肌醇周转率;基因表达;钙;刺激;抑制剂;细胞;磷酸化;转录;肝;

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1. PROTEIN KINASES AND PHOSPHATASES MODULATE C-FOS EXPRESSION IN RAT HEPATOCYTES - EFFECTS OF ANGIOTENSIN II AND PHORBOL MYRISTATE ACETATE [J] . Gonzalezespinosa C., Garciasainz JA. Life sciences . 1995,第10期

机译：蛋白激酶和磷酸酶调节大鼠肝细胞中C-FOS的表达-血管紧张素II和醋酸乙酰苯酚的作用
2. Five isoenzymes of protein kinase C are expressed in normal and STZ-diabetic rat hepatocytes: effect of phorbol 12-myristate 13-acetate [J] . Frederic Croquet, Arlette Brehier, Sophie Gil, Biochimica et biophysica acta. Molecular basis of disease: BBA . 1996,第3期

机译：蛋白激酶C的五个同工酶在正常和STZ糖尿病大鼠肝细胞中表达：佛波醇12-肉豆蔻酸酯13-乙酸酯的作用
3. RAPID, TRANSIENT EFFECTS OF THE PROTEIN KINASE C ACTIVATOR PHORBOL 12-MYRISTATE 13-ACETATE ON ACTIVITY AND TRAFFICKING OF THE RAT HIGH-AFFINITY CHOLINE TRANSPORTER [J] . S. A. G. BLACK, F. M. RIBEIRO, S. S. G. FERGUSON, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2010,第3期

机译：蛋白激酶C激活物Phorbol 12-MYRISTATE 13-ACATE对大鼠高效胆碱转运蛋白活性和运输的快速瞬态作用
4. Myristoylation of Protein Kinase C Beta II/Zeta Peptide Inhibitors, or Caveolin-1 Peptide Facilitates Rapid Attenuation of Phorbol 12-Myristate 13-Acetate (PMA) or N-Formyl-L- Methionyl-L-Leucyl-L-Phenylalanine (fMLP) Activated Leukocyte Superoxide Release [C] . Kerry-Anne A. Perkins, Kyle Bartol, Qian Chen American Peptide Symposium . 2011

机译：蛋白质激酶CβII/ Zeta肽抑制剂的MyRistoylation，或Caveolin-1肽促进了摇骨12-镁素13-乙酸酯（PMA）或N-甲酰基-1-甲硫基-L-Leucyl-L-苯丙氨酸（FMLP）的快速衰减活化白细胞超氧化物释放
5. Induction of superoxide by 12-O-tetradecanoylphorbol-13-acetate and thapsigargin, a non-phorbol ester-type tumor promoter, in peritoneal macrophages elicited from SENCAR and B6C3F1 mice: The significance of protein kinase C vs. arachidonic acid-mediated signal transduction pathways [D] . Yoon, Hyunah Lee 1992

机译：由SENCAR和B6C3F1小鼠引起的腹膜巨噬细胞中12-O-十四烷酰佛波醇13-乙酸盐和thapsigargin，一种非佛波醇酯型肿瘤启动子的超氧化物诱导作用：蛋白激酶C与花生四烯酸介导的信号转导的意义途径
6. Effects of angiotensin II and of phorbol ester on protein kinase C activity and on prostacyclin production in cultured rat aortic smooth-muscle cells. [O] . U Lang, M B Vallotton 1989

机译：血管紧张素II和佛波酯对培养的大鼠主动脉平滑肌细胞中蛋白激酶C活性和前列环素产生的影响。
7. Hormonal modulation of c-fos expression in isolated hepatocytes. Effects of angiotensin II and phorbol myristate acetate on transcription and mRNA degradation [O] . González-Espinosa Claudia, García-Sáinz J.Adolfo 1996

机译：分离的肝细胞中c-fos表达的激素调节。血管紧张素II和豆蔻酸佛波醇对转录和mRNA降解的影响
8. Effects of Phorbol Myristate Acetate, Phorbol Dibutyrate, Ethanol, Dimethylsulfoxide, Phenol, and Seven Metabolities of Phenol on Metabolic Cooperation between Chinese Hamster V79 Lung Fibroblasts [R] . Malcolm, A. R. , Mills, L. J. , McKenna, E. J. 1985

机译：佛波醇肉豆蔻酸乙酯，佛波醇二丁酸酯，乙醇，二甲基亚砜，苯酚和七种苯酚代谢对中国仓鼠V79肺成纤维细胞代谢协作的影响

PROTEIN KINASES AND PHOSPHATASES MODULATE C-FOS EXPRESSION IN RAT HEPATOCYTES - EFFECTS OF ANGIOTENSIN II AND PHORBOL MYRISTATE ACETATE

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