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首页> 外文期刊>Life sciences >Chemotoxicity and survival of tumor-bearing mice under exposure to randomized photoperiodic regimen.
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Chemotoxicity and survival of tumor-bearing mice under exposure to randomized photoperiodic regimen.

机译：暴露于随机光周期治疗方案的荷瘤小鼠的化学毒性和存活率。

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Although disruption of the circadian rhythm had been traditionally considered as a pathological sign, there is an increasing recognition that an existence of internal disorder (or chaos) in the organism's homeostasis is, to some degree, essential to the organism's well being. In this study we explored the effects of rhythm scrambling by exposure to random light/dark (RLD) alternation or by hydrocortisone administration. The variables measured were the toxicity of Adriamycin, Vincristin, Cisplatinum and Cyclophosphamide in C57Bl/6J mice and the survival of EL4 lymphoma-bearing mice, before and after chemotherapy. Rhythm alterations were determined by WBC counts and plasma Alkaline Phosphatase activity. Injections of Adriamycin, Cisplatinum and Vincristin in RLD conditions resulted in a better survival than in control groups of mice kept in LD illumination regimen, although the differences between the groups were significant only for injection of Adriamycin. RLD conditions imposed a protective 20% of the injected mice in RLD conditions still survived while, there were no survivors beyond 38 days in control group. Chemotherapy had a more prominent beneficial effect on survival in RLD group, as compared to LD group. The injections of hydrocortisone had detrimental effect on survival in both illumination schedules. However, the survival in the RLD group was still better than in the LD group. These experiments indicate that temporal disorganization has beneficial effects on lymphoma-bearing mice and could be used for development of new therapeutic modalities.
机译：尽管传统上将昼夜节律的破坏视为病理迹象，但人们日益认识到，生物体内稳态中存在内部紊乱（或混乱）在某种程度上对生物体的健康至关重要。在这项研究中，我们通过随机光照/黑暗（RLD）交替或氢化可的松给药探索了节奏扰动的影响。所测量的变量是化疗前后阿霉素，长春新碱，顺铂和环磷酰胺在C57Bl / 6J小鼠中的毒性以及荷EL4淋巴瘤小鼠的存活率。通过WBC计数和血浆碱性磷酸酶活性确定节律改变。在RLD条件下注射阿霉素，顺铂和长春新碱比在LD照射方案下饲养的对照组具有更好的存活率，尽管两组之间的差异仅在注射阿霉素时才有意义。 RLD条件强加了保护性的20％注射小鼠，在RLD条件下仍能存活，而对照组中38天以上没有存活者。与LD组相比，化学疗法对RLD组的生存有更显着的有益作用。在两种光照方案中，氢化可的松的注射均对存活有不利影响。但是，RLD组的生存率仍然比LD组更好。这些实验表明，时间混乱对荷瘤小鼠具有有益的作用，可用于开发新的治疗方法。

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