• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Change in lipid profile and impairment of endothelium-dependent relaxation of blood vessels in rats after bile duct ligation.
【24h】

Change in lipid profile and impairment of endothelium-dependent relaxation of blood vessels in rats after bile duct ligation.

机译：胆管结扎后大鼠脂质分布的变化和内皮依赖性血管松弛的损害。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hyperlipidemia, a condition normally observed in cholestatic liver disease, is also a risk factor for the development of atherosclerosis. The relationship between the elevation of lipoproteins in cholestatic liver diseases and atherosclerosis formation has not been elucidated. In this study, we propose that the impairment of endothelium-dependent relaxation (EDR) of blood vessels in cholestatic liver diseases may lead to the development of atherosclerosis. Using bile duct ligation (BDL) in rats as a model, we examined the liver function, serum lipid profile, EDR and morphologic change of the aorta from both sham operated and BDL rats. Significant increases in liver and spleen weights, serum alanine transaminase (ALT) and aspartate transaminase (AST) activities and the bilirubin level were observed in BDL rats. Upon bile duct ligation, the total and low-density lipoprotein cholesterol levels were increased but the high-density lipoprotein cholesterol and triglyceride levels were reduced. Less contractility and lowered response to acetylcholine-induced relaxation were found in aorta segments. In addition, the acetylcholine-induced relaxation was blocked by both L-NAME and 15 mM KCl. Our results suggest that both nitric oxide and endothelium-derived hyperpolarizing factor are important elements for the impairment of the EDR in BDL rats. In addition, a mild atrophy of the media of the aorta was detected in BDL rats. We conclude that the alterations of lipid profile and the mild atrophy of the media may lead to the impairment of EDR in the aorta in BDL rats, and these factors may potentiate the development of atherosclerosis.
机译：高脂血症，通常在胆汁淤积性肝病中观察到，也是动脉粥样硬化发展的危险因素。胆汁淤积性肝病中脂蛋白的升高与动脉粥样硬化形成之间的关系尚未阐明。在这项研究中，我们建议胆汁淤积性肝病中血管内皮依赖性舒张（EDR）受损可能导致动脉粥样硬化的发展。以大鼠的胆管结扎（BDL）为模型，我们检查了假手术和BDL大鼠的肝功能，血清脂质谱，EDR和主动脉的形态变化。在BDL大鼠中观察到肝脏和脾脏重量，血清丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）活性以及胆红素水平显着增加。胆管结扎后，总密度和低密度脂蛋白胆固醇水平升高，但高密度脂蛋白胆固醇和甘油三酸酯水平降低。在主动脉节段中发现收缩力较小，对乙酰胆碱引起的舒张反应降低。此外，乙酰胆碱诱导的松弛被L-NAME和15 mM KCl阻断。我们的研究结果表明，一氧化氮和内皮源性超极化因子都是BDL大鼠EDR受损的重要因素。另外，在BDL大鼠中检测到主动脉中度轻度萎缩。我们得出的结论是，脂质分布的改变和培养基的轻度萎缩可能会导致BDL大鼠主动脉EDR受损，并且这些因素可能会促进动脉粥样硬化的发展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号