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首页> 外文期刊>Life sciences >Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle.
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Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle.

机译：评价龙胆草对亚急性给药和有效成分分离的保肝作用。

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摘要

Hepatoprotective effect of Gentiana olivieri Griseb. (Gentianaceae) flowering herbs on subacute administration were studied using in vivo models in rats. For the activity assessment on carbon tetrachloride-induced hepatic damage following biochemical parameters were evaluated; plasma and hepatic tissue malondialdehyde formation, and liver tissue glutathione level, as well as plasma transaminase enzyme levels (aspartate transferase and alanine transferase). Results of biochemical tests were also confirmed by histopathological examination. Through bioassay-guided fractionation procedures isoorientin, a known C-glycosylflavone, was isolated from the ethyl acetate fraction as the active antihepatotoxic constituent by silica gel column chromatography. Isoorientin exhibited significant hepatoprotective effect at 15 mg/kg b.w. dose.
机译：龙胆秦ent的保肝作用。使用大鼠体内模型研究了（龙胆科）亚急性给药的开花草药。为了评估四氯化碳引起的肝损伤的活性，根据生化参数进行了评估;血浆和肝组织中丙二醛的形成，肝组织谷胱甘肽水平以及血浆转氨酶水平（天冬氨酸转移酶和丙氨酸转移酶）。组织化学检查也证实了生化检查的结果。通过生物测定指导的分级分离程序，通过硅胶柱色谱法从乙酸乙酯级分中分离出了一种异东方素（一种已知的C-糖基黄酮）作为抗肝毒性活性成分。异Orientin在15 mg / kg b.w时显示出显着的肝保护作用。剂量。

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