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Mechanotransduction and focal adhesions

机译:机械转导和粘连

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摘要

Cellular FAs (focal adhesions) respond to internal and external mechanical stresses which make them prime candidates for mechanotransduction. Recent observations showed that the FA proteins including vinculin, FAK (FA kinase) and p130Cas are crucial for the ability of cells to transmit forces and to generate cytoskeletal tension. When mechanically stimulated, cells respond by modulating the spreading area, remodel the actin cytoskeleton, activate actomyosin interactions, recruit integrins and reinforce FAs and cytoskeletal structures. These complex cellular responses are orchestrated such that mechanical stresses within the FA complex remained within a narrow range.
机译:细胞FAs(粘着斑)对内部和外部机械应力作出反应,使其成为机械传导的主要候选对象。最近的观察表明,FA蛋白包括纽蛋白,FAK(FA激酶)和p130Cas对细胞传递力和产生细胞骨架张力的能力至关重要。当受到机械刺激时,细胞会通过调节扩散区域,重塑肌动蛋白细胞骨架,激活肌动球蛋白相互作用,募集整联蛋白并增强FA和细胞骨架结构来做出反应。精心安排这些复杂的细胞反应,使FA复合物中的机械应力保持在狭窄范围内。

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