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首页> 外文期刊>Cell biology international. >Gene network of a phosphoglycerate mutase in muscle wasting in mice
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Gene network of a phosphoglycerate mutase in muscle wasting in mice

机译：小鼠肌肉萎缩中磷酸甘油酸突变酶的基因网络

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We previously identified the insertion of an intracisternal A-particle retrotransposons (IAPs) sequence in a gene, 9630033F20Rik, that contains domains involved in glycolysis from a mouse model called lethal wasting (lew). However, because both IAP insertion and the muation of vesicle-associated membrane protein 1 (VAMP1) were discovered from lew, the impact of the IAP insertion and Vamp1 on the lew mouse phenotype needs further investigation. In this study, the effect of the 9630033F20Rik and Vamp1 on glycolysis and muscle-wasting genes in heart, muscle, and brain tissues was further investigated using data of gene expression profiles in these tissues. Our data indicated that the expression levels of 9630033F20Rik and Vamp1 are not associated with each other. While 9630033F20Rik affects the expression of several key genes in pathways of glycolysis and muscle wasting, Vamp1 affects a different set of genes, with fewer numbers. In situ hybridization indicated that the expression of 9630033F20Rik is different in musculoskeletal tissues between the muscle-wasting mouse model and the wild-type model. Our data indicated that 9630033F20Rik may play an important role in muscle wasting and that it has a distinguished characterization of gene network. Our data also suggest that both 9630033F20Rik and Vamp1 play functional roles in muscle development and lead to the muscle-wasting phenotype when they are mutated.
机译：我们先前鉴定了在基因9630033F20Rik中插入了脑池内A粒子逆转座子（IAPs）序列，该基因包含涉及从称为致死性浪费（lew）的小鼠模型进行糖酵解的域。但是，由于IAP插入和囊泡相关膜蛋白1（VAMP1）的突变均发现于le，因此IAP插入和Vamp1对1小鼠表型的影响尚待进一步研究。在这项研究中，使用这些组织中基因表达谱的数据进一步研究了9630033F20Rik和Vamp1对心脏，肌肉和脑组织中糖酵解和肌肉消瘦基因的影响。我们的数据表明9630033F20Rik和Vamp1的表达水平彼此不相关。 9630033F20Rik影响糖酵解和肌肉消耗途径中几个关键基因的表达，而Vamp1影响另一组基因，但数量较少。原位杂交表明9630033F20Rik在肌肉消瘦小鼠模型和野生型模型之间的肌肉骨骼组织中表达不同。我们的数据表明9630033F20Rik可能在肌肉消瘦中起重要作用，并且它具有明显的基因网络特征。我们的数据还表明9630033F20Rik和Vamp1在肌肉发育中均发挥功能性作用，并在突变时导致肌肉消瘦的表型。

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