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首页> 外文期刊>Cell biology international. >Effects of leukaemia inhibitory factor on endometrial receptivity and its hormonal regulation in rabbits.
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Effects of leukaemia inhibitory factor on endometrial receptivity and its hormonal regulation in rabbits.

机译：白血病抑制因子对家兔子宫内膜容受性及其激素调节的影响。

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摘要

The effects of hormones on production of leukaemia inhibitory factor (LIF) and the uterine receptivity in rabbits were studied. In ovariectomised rabbits, LIF protein was not detected in control but upregulated by progesterone alone. Oestrogen had a slightly negative effect when the rabbits were treated with both oestrogen and progesterone. Mifepristone (Mi) inhibited the progesterone-stimulated production of LIF in rabbit uterus. The transfer of embryos to LIF-treated recipients significantly increased pregnancy rate (70%) and implantation rate (27%) as compared with control (pregnancy rate=40% and implantation rate=17%). The transfer of embryos to LIF and mifepristone-treated recipients significantly decreased pregnancy rate (30%) and implantation rate (9%). The results indicated that LIF protein had a beneficial effect on uterine receptivity and mifepristone prevented this effect.
机译：研究了激素对家兔白血病抑制因子（LIF）产生和子宫接受性的影响。在切除卵巢的兔子中，在对照中未检测到LIF蛋白，但仅由孕激素上调。当兔子同时接受雌激素和孕激素治疗时，雌激素的作用会稍有负面。米非司酮（Mi）抑制黄体酮刺激的兔子宫中LIF的产生。与对照组（怀孕率= 40％，植入率= 17％）相比，将胚胎转移至接受LIF治疗的受体可显着提高妊娠率（70％）和着床率（27％）。胚胎向LIF和米非司酮治疗的受体的转移显着降低了怀孕率（30％）和着床率（9％）。结果表明，LIF蛋白对子宫的接受性具有有益作用，而米非司酮则阻止了这种作用。

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