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首页> 外文期刊>Cell and Tissue Research >Treatment of long bone defects and non-unions: From research to clinical practice
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Treatment of long bone defects and non-unions: From research to clinical practice

机译：长骨缺损和不愈合的治疗：从研究到临床实践

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摘要

The treatment of long bone defects and nonunions is still a major clinical and socio-economical problem. In addition to the non-operative therapeutic options, such as the application of various forms of electricity, extracorporeal shock wave therapy and ultrasound therapy, which are still in clinical use, several operative treatment methods are available. No consensus guidelines are available and the treatments of such defects differ greatly. Therefore, clinicians and researchers are presently investigating ways to treat large bone defects based on tissue engineering approaches. Tissue engineering strategies for bone regeneration seem to be a promising option in regenerative medicine. Several in vitro and in vivo studies in small and large animal models have been conducted to establish the efficiency of various tissue engineering approaches. Neverthelsss, the literature still lacks controlled studies that compare the different clinical treatment strategies currently in use. However, based on the results obtained so far in diverse animal studies, bone tissue engineering approaches need further validation in more clinically relevant animal models and in clinical pilot studies for the translation of bone tissue engineering approaches into clinical practice.
机译：长骨缺损和骨不连的治疗仍然是主要的临床和社会经济问题。除了仍在临床上使用的非手术治疗选择（例如各种形式的电的应用，体外冲击波治疗和超声治疗）以外，还有几种手术治疗方法可用。目前尚无共识指南，并且此类缺陷的处理方法也存在很大差异。因此，临床医生和研究人员目前正在研究基于组织工程方法治疗大骨缺损的方法。骨再生的组织工程策略似乎是再生医学中的一个有前途的选择。已经在小型和大型动物模型中进行了一些体外和体内研究，以建立各种组织工程方法的效率。没关系，文献仍然缺乏对照研究，无法比较当前使用的不同临床治疗策略。但是，根据迄今为止在各种动物研究中获得的结果，骨组织工程方法需要在更具临床相关性的动物模型和临床先导研究中进一步验证，以将骨组织工程方法转化为临床实践。

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