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首页> 外文期刊>Cell and Tissue Research >Collagens and proteoglycans of the cornea: importance in transparency and visual disorders
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Collagens and proteoglycans of the cornea: importance in transparency and visual disorders

机译：角膜的胶原蛋白和蛋白聚糖：在透明性和视觉障碍中的重要性

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摘要

The cornea represents the external part of the eye and consists of an epithelium, a stroma and an endothelium. Due to its curvature and transparency this structure makes up approximately 70 % of the total refractive power of the eye. This function is partly made possible by the particular organization of the collagen extracellular matrix contained in the corneal stroma that allows a constant refractive power. The maintenance of such an organization involves other molecules such as type V collagen, FACITs (fibril-associated collagens with interrupted triple helices) and SLRPs (small leucine-rich proteoglycans). These components play crucial roles in the preservation of the correct organization and function of the cornea since their absence or modification leads to abnormalities such as corneal opacities. Thus, the aim of this review is to describe the different corneal collagens and proteoglycans by highlighting their importance in corneal transparency as well as their implication in corneal visual disorders.
机译：角膜代表眼睛的外部，由上皮，基质和内皮组成。由于其曲率和透明度，该结构约占眼睛总屈光力的70％。角膜基质中所含的胶原蛋白细胞外基质的特定组织可以部分实现该功能，从而可以保持恒定的屈光力。这种组织的维持涉及其他分子，例如V型胶原蛋白，FACITs（具有三重螺旋间断的原纤维相关胶原蛋白）和SLRPs（富含亮氨酸的小蛋白聚糖）。这些成分在保持正确的角膜组织和功能中起着至关重要的作用，因为它们的缺失或修饰会导致异常，例如角膜混浊。因此，本综述的目的是通过强调不同的角膜胶原蛋白和蛋白聚糖在角膜透明性中的重要性及其对角膜视觉障碍的影响来描述它们。

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