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首页> 外文期刊>Cell and Tissue Research >Cellular regulators of protein kinase CK2.
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Cellular regulators of protein kinase CK2.

机译:蛋白激酶CK2的细胞调节剂。

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摘要

Protein phosphorylation is a key regulatory post-translational modification and is involved in the control of many cellular processes. Protein kinase CK2, formerly known as casein kinase II, which is a ubiquitous and highly conserved protein serine/threonine kinase, plays a central role in the control of a variety of pathways in cell proliferation, transformation, apoptosis and senescence. An understanding of the regulation of such a central protein kinase would greatly help our comprehension of the regulation of many pathways in cellular regulation. A number of reviews have addressed the detection, the development, and the characterization of inhibitors of CK2. The present review focuses on possible natural regulators of CK2, i.e. proteins and other cellular factors that bind to CK2 and thereby regulate its activity.
机译:蛋白质磷酸化是关键的翻译后修饰修饰,参与许多细胞过程的控制。蛋白激酶CK2(以前称为酪蛋白激酶II)是一种普遍存在且高度保守的蛋白丝氨酸/苏氨酸激酶,在控制细胞增殖,转化,凋亡和衰老的各种途径中起着核心作用。对这种中央蛋白激酶调节的理解将极大地帮助我们理解细胞调节中许多途径的调节。许多评论都针对CK2抑制剂的检测,开发和表征。本综述着重于CK2的可能天然调节剂,即结合CK2并由此调节其活性的蛋白质和其他细胞因子。

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